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FTO
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Respiratory ciliated cells, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer (By similarity). May also exist as homodimer (By similarity).
Molecular function
Dioxygenase, Oxidoreductase, Transferase
More Types Infomation
- Rabbit Anti-FTO Recombinant Antibody (clone JM98-30) (MRO-0611-CN)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
- Recombinant Human Anti-human FTO Antibody scFv Fragment (MHH-373-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: WB, Neut, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
- Recombinant Anti-human FTO Antibody (MOB-373)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FC, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IP, FuncS
- Recombinant Anti-human FTO Antibody scFv Fragment (MOB-373-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, IF, FuncS
- Recombinant Anti-human FTO Antibody Fab Fragment (MOB-373-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IF, FuncS
- Recombinant Human Anti-human FTO Antibody Fab Fragment (MHH-373-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: WB, IHC, FuncS
- Recombinant Mouse Anti-FTO Soluble TCR (2C) (KIH) (VS-0622-YF5531)
-
- Species Reactivity: Human
- Epitope: LSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-FTO Soluble TCR (2C) (C-Cys) (VS-0622-YF2823)
-
- Species Reactivity: Human
- Epitope: LSPFPFDL
- MHC: H-2Ld
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P
- Recombinant Mouse Anti-FTO Soluble TCR (clone 2C) (scTCR-115CQ-S(P))
-
- Species Reactivity: Human
- Epitope: LSPFPFDL
- MHC: H-2Ld
- Recombinant Mouse Anti-FTO Soluble TCR (2C) (ZIP-Fos/ZIP-Jun) (VS-0622-YF115)
-
- Species Reactivity: Human
- Epitope: LSPFPFDL
- MHC: H-2Ld
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IHC, IF
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