Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, RAS pathway related proteins, Transporters
Intracellular, Membrane (different isoforms)
Group enriched (Inhibitory neurons, Excitatory neurons)
Not detected in immune cells
Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, fHDF/TERT166, hTERT-RPE1, RPMI-8226, U-138 MG)
Heterotetramer. Forms heterotetrameric channels composed of two zeta subunits (GRIN1), and two epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) (in vitro) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Can also form heterotetrameric channels that contain at least one zeta subunit (GRIN1), at least one epsilon subunit, plus GRIN3A or GRIN3B. In vivo, the subunit composition may depend on the expression levels of the different subunits. Found in a complex with GRIN1, GRIN3A and PPP2CB (By similarity). Found in a complex with GRIN1 and GRIN3B (By similarity). Interacts with AIP1 (By similarity). Interacts with HIP1 and NETO1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (By similarity). Interacts with PDZ domains of PATJ and DLG4. Interacts with LRFN2 (By similarity). Interacts with RPH3A and DLG4; this ternary complex regulates NMDA receptor composition at postsynaptic membranes (By similarity). Interacts with SORCS2 (By similarity). Interacts with ARC; preventing ARC oligomerization (By similarity).
Ion channel, Ligand-gated ion channel, Receptor
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For Research Use Only. Not For Clinical Use.