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LRIG1
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Protein class
Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enriched (Astrocytes)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Cell line enhanced (Daudi, hTEC/SVTERT24-B, U-698)
Interaction
Interacts (via extracellular LRR and Ig-like domains) with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 (via extracellular domain) (PubMed:15282549). The physiological relevance of the interaction is controversial; LRIG1 may have low affinity for EGFR, and interaction may occur only when high levels of both proteins are present (PubMed:25765764).
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FC, ICC, IHC
- Recombinant Rat Anti-Lrig1 Antibody (CBL375) (NEUT-1700CQ)
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- Species Reactivity: Mouse
- Type: IgG2a
- Application: BL
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For Research Use Only. Not For Clinical Use.