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MFN2
Mfn2 (Mitofusin 2) is a Protein Coding gene. This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Diseases associated with Mfn2 include Neuropathy, Hereditary Motor And Sensory, Type Via, With Optic Atrophy and Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2A2a.
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms homomultimers and heteromultimers with MFN1 (PubMed:26085578). Oligomerization is essential for mitochondrion fusion (Probable). Interacts with VAT1 (By similarity). Interacts with STOML2; may form heterooligomers (PubMed:17121834). Interacts (phosphorylated) with PRKN (PubMed:23620051). Interacts with EIF2AK3 (By similarity). Interacts with THG1L; THG1L probably functions as a guanyl-nucleotide exchange factor/GEF, activating MFN2.
Molecular function
Hydrolase
More Types Infomation
- Rabbit Anti-MFN2 Polyclonal Antibody (MRO-2034-CN) (MRO-2034-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, FC
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC, ICC
- Rabbit Anti-Mfn2 Recombinant Antibody (clone rN153/5.1) (VS-0422-LC147)
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ICC, WB, IF
- Mouse Anti-Mfn2 Recombinant Antibody (clone mN153/5.1) (VS-0422-LC146)
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- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: ICC, WB, IF
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC
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For Research Use Only. Not For Clinical Use.