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MMP3

Predicted to enable metalloendopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to interleukin-1; and response to estradiol. Located in several cellular components, including cell body; dendrite; and extracellular space. Part of protein-containing complex. Biomarker of several diseases, including abdominal aortic aneurysm; degenerative disc disease; gastric ulcer; glomerulonephritis (multiple); and primary biliary cholangitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); carcinoma (multiple); end stage renal disease; osteoarthritis; and von Hippel-Lindau disease. Orthologous to human MMP3 (matrix metallopeptidase 3).
Protein class

Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Basal respiratory cells, Early spermatids, Basal prostatic cells, Fibroblasts, Extravillous trophoblasts, Prostatic glandular cells, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BJ, BJ hTERT+, fHDF/TERT166)

Molecular function

Hydrolase, Metalloprotease, Protease

More Types Infomation

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