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MYH6

Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. The gene is located ~4kb downstream of the gene encoding the beta heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect 3.
Protein class

Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enriched (Cardiomyocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (NTERA-2)

Interaction

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Molecular function

Actin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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