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PLD2
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Protein class
Enzymes, Metabolic proteins, RAS pathway related proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with PIP5K1B (PubMed:11032811). Interacts with EGFR (By similarity).
Molecular function
Hydrolase
More Types Infomation
Related Signaling Pathways
Ras Signaling Pathway
-
- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.