Transcription factors
Intracellular
Cell type enriched (Skeletal myocytes)
Not detected in immune cells
Cell line enhanced (HEK93, HEL, JURKAT, REH, RH-30, SCLC-21H, U-266/70)
Interacts (via N-terminus) with RIT2; the interaction controls POU4F1 transactivation activity on some neuronal target genes. Isoform 1 interacts with POU4F2; this interaction inhibits both POU4F1 DNA-binding and transcriptional activities. Isoform 1 interacts (C-terminus) with ESR1 (via DNA-binding domain); this interaction decreases the estrogen receptor ESR1 transcriptional activity in a DNA- and ligand 17-beta-estradiol-independent manner.
Developmental protein, DNA-binding
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For Research Use Only. Not For Clinical Use.