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PRKCQ
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways.
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, NK-cells, T-cells, Oligodendrocyte precursor cells, Astrocytes, dendritic cells)
Immune cell specificity
Group enriched (T-reg, memory CD8 T-cell, memory CD4 T-cell, gdT-cell, naive CD4 T-cell, MAIT T-cell, naive CD8 T-cell, NK-cell)
Cell line specificity
Cell line enhanced (HEL, JURKAT, MOLT-4)
Interaction
Part of a lipid raft complex composed at least of BCL10, CARD11, MALT1 and IKBKB (PubMed:16356855). Interacts with GLRX3 (via N-terminus) (PubMed:10636891). Interacts with ECT2 (PubMed:15254234). Interacts with CCDC88A/GIV; the interaction leads to phosphorylation of CCDC88A and inhibition of its guanine nucleotide exchange factor activity (PubMed:23509302). Interacts with PRKCH upstream open reading frame 2; the interaction leads to inhibition of kinase activity (PubMed:34593629).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, FuncS
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- Species Reactivity: Human
- Type: IgG
- Application: WB, IHC-P, FC
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- Species Reactivity: Human
- Application: WB, ELISA
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: ELISA, WB
- Chicken Anti-PRKCQ Polyclonal IgY (BRD-0438MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.