Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets
Intracellular
Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, NK-cells, dendritic cells)
Immune cell enhanced (basophil)
Cell line enhanced (HMC-1)
Like other cAMP-dependent protein kinases, the inactive holoenzyme is probably composed of 2 PRKX catalytic subunits and a dimer of regulatory subunits. Interacts (cAMP-dependent) specifically with the regulatory subunits PRKAR1A and PRKAR1B. Compared to other cAMP-dependent serine/threonine protein kinases, does not interact with the 2 other PKA regulatory subunits PRKAR2A and PRKAR2B. Interacts with cAMP-dependent protein kinase inhibitor/PKI proteins; inhibits PRKX. Interacts with GPKOW. Interacts with SMAD6. Interacts with PKD1; involved in differentiation and controlled morphogenesis of the kidney. Interacts with PIN1 (via WW domain).
Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase
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For Research Use Only. Not For Clinical Use.