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SIGLEC8
Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490)
Protein class
CD markers, Plasma proteins
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (granulocytes, Kupffer cells, Microglial cells)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Cell line enriched (HMC-1)
More Types Infomation
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- Species Reactivity: Human
- Application: WB
- Mouse Anti-SIGLEC8 Recombinant Antibody; scFv Fragment (HPAB-S0136-YC-S(P)) (HPAB-S0136-YC-S(P))
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
- Mouse Anti-SIGLEC8 Recombinant Antibody; Fab Fragment (HPAB-S0136-YC-F(E)) (HPAB-S0136-YC-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, FC
- Mouse Anti-SIGLEC8 Recombinant Antibody (HPAB-S0136-YC) (HPAB-S0136-YC)
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- Species Reactivity: Human
- Type: Mouse IgG2, κ
- Application: ELISA, FC
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: WB, ELISA, FC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized antibody
- Application: WB, ELISA, FC
-
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, ELISA, FC
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For Research Use Only. Not For Clinical Use.