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ISG15
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Proximal enterocytes, Paneth cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V, HeLa, SK-MEL-30)
Interaction
Homodimer; disulfide-linked (PubMed:2440890). Interacts with, and is conjugated to its targets by UBE1L (E1 enzyme) and UBE2E2 (E2 enzyme) (PubMed:11157743, PubMed:15131269). Interacts with NEDD4 (PubMed:18305167). (Microbial infection) Interacts with vaccinia virus protein E3. (Microbial infection) Interaction with influenza B NS1 protein inhibits its conjugation.
More Types Infomation
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC/IF, WB
- Mouse Anti-Mouse ISG15 Antibody (MOB-125CQ)
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- Species Reactivity: Mouse
- Type: Mouse IgG2a, κ
- Application: ELISA, WB, IP, IF
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
-
- Species Reactivity: Human
- Application: WB
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
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- Derivation: Rabbit
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC, FC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.