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JAG1

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
JAG1
Protein class

CD markers, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Squamous epithelial cells, Basal squamous epithelial cells, Endometrial ciliated cells, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (HBEC3-KT, hTERT-HME1, U-251 MG)

Interaction

Interacts with NOTCH2 and NOTCH3 (By similarity). Interacts with NOTCH1 (in the presence of calcium ions) (PubMed:18660822).

Molecular function

Developmental protein

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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