Enzymes, RAS pathway related proteins
Intracellular
Low cell type specificity
Low immune cell specificity
Cell line enhanced (HDLM-2)
Found in a complex, at least composed of ITGB1BP1, KRIT1 and RAP1A (PubMed:17916086). Interacts (active GTP-bound form preferentially) with KRIT1 (via C-terminus FERM domain); the interaction does not induce the opening conformation of KRIT1 (PubMed:17916086). In its GTP-bound form interacts with PLCE1 and RADIL (PubMed:11022048, PubMed:12444546, PubMed:17704304). Interacts with SGSM1, SGSM2 and SGSM3 (PubMed:17509819). Interacts (via GTP-bound active form) with RAPGEF2 (via Ras-associating domain) (PubMed:11359771, PubMed:10608844). Interacts with TBC1D21 (By similarity). Interacts with RAP1GDS1 (PubMed:20709748).
Hydrolase
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For Research Use Only. Not For Clinical Use.