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RXRG
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Protein class
Cancer-related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Skeletal myocytes, Melanocytes, Cone photoreceptor cells, Muller glia cells, Astrocytes, Sertoli cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SK-MEL-30)
Interaction
Homodimer (By similarity). Heterodimer with a RAR molecule (PubMed:28167758). Binds DNA preferentially as a RAR/RXR heterodimer (PubMed:28167758). Interacts with RARA (PubMed:28167758).
Molecular function
DNA-binding, Receptor
More Types Infomation
Related Signaling Pathways
PPAR Signaling Pathway
Related Diseases
Throid Cancer
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- Species Reactivity: Human
- Application: WB
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For Research Use Only. Not For Clinical Use.