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transferrin-ABR immunotoxin (AGTO-G074A)

This immunotoxin was achieved by conjugating/fusing the transferrin to Abrin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the abrin is subsequently engulfed and enters the inner parts of the cell where it reacts with a ribosomal subunit. It interferes with the normal protein synthesis process of the cell and then inhibits cell protein synthesis. It was designed for treatment of myelogenous leukemia.      

Specifications
Host
Human
Species Reactivity
Human
Molecule Class
transferrin-ABR
Toxin Description
Abrin is a highly toxic toxalbumin found in the seeds of the rosary pea (jequirity pea). It is a ribosome inhibiting protein and the toxin can also be found in the seeds of the castor oil plant. Abrin is a water-soluble lectin. Abrin in powdered form is yellowish-white. It is a stable substance and can withstand extreme environmental conditions.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
myelogenous leukemia
Target
Alternative Names
BDP1; B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB; TFC5; TFNR; TAF3B1; TFIIIB; TFIIIB90; HSA238520
Entrez Gene ID
55814
UniProt ID
A6H8Y1

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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