Products

Anti-CD30 Immunocytokine, scFv (HRS4)-IL2 (ACFP-SH126)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD30 scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD30 as well as the biological activity of IL2. The antibody-cytokine fusion protein enhanced the cytolysis of CD30+ tumor cells and IFN-γ secretion by NK cells, and increased the activation of resting NK cells. This immunocytokine was designed for treating CD30-positive lymphoma.      

Specifications
Target
CD30
Molecule Class
scFv-IL2
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
HRS4
Related Disease
CD30-positive lymphoma
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily; member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen
Entrez Gene ID
943
UniProt ID
A5D8T4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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