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anti-CD5 immunotoxin H65 (scFv)-Gel (AGTO-L053G)

This immunotoxin was achieved by conjugating/fusing the Anti-CD5 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cells which express the CD5 antigen. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
H65
Molecule Class
scFv-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
Alternative Names
CD5; CD5 molecule; T1; LEU1; T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; T cell leukemias
Entrez Gene ID
921
UniProt ID
P06127

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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