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Anti-ERBB2 Intrabody [Tat] (IAB-B008(T))

Recombinant anti-ERBB2 intrabody in fusion with HIV Tat targetes to the lumen of the endoplasmic reticulum prevent the transit of EGFR or the related ErbB2 molecule to the cell surface, thereby inactivating their transforming potential, expressed in CHO cells.      

Specifications
Immunogen
human erb-b2 receptor tyrosine kinase 2
Host
human
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
human
Applications
Formats of immunological tests: Immunocytochemistry; Neutralization; Functional studies
Target
Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2
Entrez Gene ID
2064
UniProt ID
P04626

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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