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Anti-GPA33 immunotoxin (scFv)-α-sar (AGTO-G034F)

This immunotoxin was achieved by conjugating/fusing the Anti-GPA33 scFv to α-sarcin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to GPA33 tumor antigen expressing cells. Once bind, alpha-Sarcin enters into the cells by receptor-mediated endocytosis and interacts with a single bond in the targeted ribosome and breaks it, causing the ribosome to be inactivated. It was designed for treatment of colon cancer.      

Specifications
Host
Mouse
Species Reactivity
Human
Molecule Class
scFv-α-sar
Toxin Description
Alpha-Sarcin is a ribosome-inactivating protein produced in the mold Aspergillus giganteus. Specifically, alpha-sarcin cleaves the a portion of ribosomal RNA that forms the small ribosomal substrate. The high specificity of alpha-sarcin and its efficiency of cleavage are point of study and also account for this protein's very high toxicity level.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
colon cancer
Target
Alternative Names
GPA33; glycoprotein A33 (transmembrane); A33; cell surface A33 antigen; transmembrane glycoprotein A33; α-sar; α-sarcin
Entrez Gene ID
10223
UniProt ID
Q99795

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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