Recombinant Human Antibody (b12) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-HIV-1 gp120 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 Neutralization of HIV-1 gp120 by monoclonal antibody (mAB)IgG1-b12.
Flow cytometric analysis of theinfection of HeLa-CD4 cells by NL4-3-EGFP virus with the HIV-1LAI envelope protein. Significant neutralization can be seen by comparing the C4 quadrants(0.9 versus 5.9% EGFP-positive cells).
Pang, S., Yu, D., An, D. S., Baldwin, G. C., Xie, Y., Poon, B., ... & Chen, I. S. (2000). Human immunodeficiency virus Env-independent infection of human CD4− cells. Journal of virology, 74(23), 10994-11000.
Figure 2 Neutralization of HIV-1 gp120 by monoclonal antibody (mAB)IgG1-b12.
Percentage of EGFP-positive cellsfollowing infection by IgG1-b12-treated virus relative to virus treated identicallybut without antibody.
Pang, S., Yu, D., An, D. S., Baldwin, G. C., Xie, Y., Poon, B., ... & Chen, I. S. (2000). Human immunodeficiency virus Env-independent infection of human CD4− cells. Journal of virology, 74(23), 10994-11000.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-380 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06); Fab Fragment | Neut, FuncS | Human Fab |
PFBZ-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 50.1); Fab Fragment | Neut | Mouse Fab |
PFBW-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 58.2); Fab Fragment | Neut | Mouse Fab |
FAMAB-0177CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone BAT123); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
FAMAB-0178CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone C beta 1); Fab Fragment | WB, Neut | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (D59/A2) | ELISA | Mouse antibody |
MRO-042LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (F58/H3) | ELISA | Mouse antibody |
MRO-043LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P1/D12) | ELISA | Mouse antibody |
MRO-044LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P4/D10) | ELISA | Mouse antibody |
MRO-045LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3617CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 1F4) | ELISA | Mouse IgG |
MRO-3618CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone V902) | ELISA | Mouse IgG1 |
MRO-3619CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 522-149) | ELISA | Mouse IgG |
MRO-3620CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone A9) | ELISA, WB | Mouse IgG1 |
MRO-3621CQ | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone B4) | ELISA, WB | Mouse IgM |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3135CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH51); scFv Fragment | ELISA | Human scFv |
MRO-3136CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH52); scFv Fragment | ELISA | Human scFv |
MRO-3137CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH53); scFv Fragment | ELISA | Human scFv |
MRO-3138CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH54); scFv Fragment | ELISA | Human scFv |
MRO-3139CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone CH55); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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