Recombinant Human Antibody (DH427) is capable of binding to HIV-1 gp120, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-HIV-1 gp120 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-HIV-1 gp120 proteins mAb and CL of human light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
Figure 1 Cross-competition of sCD4-Ig binding to the CAP206 6-month Env by DH427, DH428, and RSV antibody Synagis determined by ELISA.
As expected from their sensitivity to changes at position 463, DH427 and DH428 competed for binding of soluble CD4 to CAP206 6-month Env.
Bradley, T., Fera, D., Bhiman, J., Eslamizar, L., Lu, X., Anasti, K., ... & Stolarchuk, C. (2016). Structural constraints of vaccine-induced tier-2 autologous HIV neutralizing antibodies targeting the receptor-binding site. Cell reports, 14(1), 43-54.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-380 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06); scFv Fragment | Neut, FuncS | Human scFv |
PFBZ-164 | Human Anti-HIV-1 gp120 Recombinant Antibody; Fab Fragment (PFBZ-164) | Neut | Human Fab |
PFBZ-165 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone GL-VRC01); Fab Fragment | Neut | Human Fab |
MRO-3516CQ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT142); scFv Fragment | Neut, ELISA | Human scFv |
MRO-3649CQ-S(P) | Rat Anti-HIV-1 gp120 Recombinant Antibody (clone 62c); scFv Fragment | ELISA | Rat scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-517 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 44-VRC13.01); Fab Fragment | Neut | Human Fab |
PFBL-518 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 45-46M2); Fab Fragment | ELISA, Neut | Human Fab |
PFBL-519 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 45-VRC01.H5.F-185917); Fab Fragment | WB, FuncS | Human Fab |
FAMAB-0177CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone BAT123); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
FAMAB-0178CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone C beta 1); Fab Fragment | WB, Neut | Chimeric (mouse/human) Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91H9) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-132LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT123) | ELISA, WB, IF, Neut | Mouse antibody |
MRO-133LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT267) | ELISA, WB, Neut | Mouse antibody |
MRO-134LC | Anti-HIV-1 gp120 Recombinant Antibody (BAT085) | ELISA, WB, IF, Neut | Mouse antibody |
MRO-150LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-4) | ELISA, Inhib, FC, Neut, RIPA, DB, IP | Mouse antibody |
MRO-152LC | Anti-HIV-1 gp120 Recombinant Antibody (G3-136) | Neut, ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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