Recombinant Mouse Antibody (NC-1) is capable of binding to HIV-1 gp41, expressed in mammalian cells.
Figure 1 Binding of MAb NC-1 to peptides and peptide complexes using a dot blot assay.
The binding of the antisera (1:100) and MAb (10 mg/ml) to the individual peptides and peptide complexes was detected by dot blot assay. The complex N-36/C-34 was prepared by mixing peptides N-36 and C-34 in PBS at equimo- lar concentrations (2 mM).
Jiang, S., Lin, K., Zhang, L., & Debnath, A. K. (1999). A screening assay for antiviral compounds targeted to the HIV-1 gp41 core structure using a conformation-specific monoclonal antibody. Journal of virological methods, 80(1), 85-96.
Figure 2 Binding of NC-1 to the model polypeptides containing N and C peptides by ELISA analysis.
Each of the N51(L6)C43, N36(L6)C34, and N34(L6)C28 polypeptides (∼1 μM) were used to coat wells of a microplate. The binding of the purified NC-1 IgG at the indicated concentrations to each coated polypeptide was tested by ELISA.
Jiang, S., Lin, K., & Lu, M. (1998). A conformation-specific monoclonal antibody reacting with fusion-active gp41 from the human immunodeficiency virus type 1 envelope glycoprotein. Journal of virology, 72(12), 10213-10217.
Figure 3 Binding of MAb NC-1 to transmembrane glycoproteins expressed on HIV-infected cells by flow cytometric analysis.
HIV-1IIIB-infected cells were reacted with the MAbs NC-1 (A) and 2F5 (B) (5 μg of IgG/ml) in the presence or absence of sCD4 (10 μg/ml) and analyzed by flow cytometry. Binding of NC-1 to HIV-2ROD-infected cells was also tested (C). Normal mouse (NM) IgG was used as a control.
Jiang, S., Lin, K., & Lu, M. (1998). A conformation-specific monoclonal antibody reacting with fusion-active gp41 from the human immunodeficiency virus type 1 envelope glycoprotein. Journal of virology, 72(12), 10213-10217.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-185 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8062) | WB, ELISA, FuncS | Human IgG |
PABL-186 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 2F5) | WB, Neut, FuncS | Human IgG |
PABL-187 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC176) | Neut, FuncS | Human IgG |
PABL-188 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 3BC315) | Neut, FuncS | Human IgG |
PABL-189 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone m66) | Neut, FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBZ-068 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 1583); Fab Fragment | Neut | Mouse Fab |
PFBW-068 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone D5); Fab Fragment | WB, ELISA | Human Fab |
PFBC-069 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone HK20); Fab Fragment | Neut, ELISA | Human Fab |
PFBL-555 | Human Anti-HIV-1 gp41 Recombinant Antibody (clone 8066); Fab Fragment | Neut | Human Fab |
PFBL-556 | Mouse Anti-HIV-1 gp41 Recombinant Antibody (clone 11f10); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-025LC | Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG3) | ELISA | Human antibody |
MRO-026LC | Anti-HIV-1 gp41 Recombinant Antibody (4E10-IgG1) | ELISA | Human antibody |
MRO-040LC | Anti-HIV-1 gp41 Recombinant Antibody (M66.6) | ELISA | Human antibody |
MRO-025LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG3) | ELISA | Human antibody |
MRO-026LC-S(P) | Anti-HIV-1 gp41 Recombinant Antibody scFv Fragment (4E10-IgG1) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC746 | A*2402/HIV-1 gp41 (RYLKDQQLL) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-336 | Mouse Anti-HIV-1 gp41 Recombinant Antibody; scFv Fragment (PSBC-336) | ELISA, Neut | Mouse scFv |
PSBS-0051 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.4); scFv Fragment | ELISA, Neut, FuncS | Monkey scFv |
PSBS-0052 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.9); scFv Fragment | ELISA, FuncS | Monkey scFv |
PSBS-0053 | Monkey Anti-HIV-1 gp41 Recombinant Antibody (Clone DH570.mut58); scFv Fragment | ELISA, Neut, FuncS | Monkey scFv |
PABJ-0083-S(P) | Human Anti-HIV-1 gp41 Recombinant Antibody (clone VRC42.04); scFv Fragment | ELISA | Human scFv |
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