Anti-HRSV F Recombinant Antibody (MEDI-493) (CAT#: MRO-1209LC)
This product is a recombinant humanized anti-Respiratory syncytial virus monoclonal antibody. MEDI-493 specifically binds to F glycoprotein associated with RSV and can be potentially used in the diagnosis and treatment of Respiratory syncytial virus infection.
Specific Inquiry
Neut
Figure 1 Plaque-reduction assay of neutralization of RSV by MEDI-493.
O ^ RSV Long (A subtype) -f- MEDI-493; A = RSV 18537 (B subtype) H- MEDI-493; = RSV Long -I- RSV intravenous immune globulin (lot 4).
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus
Neut
Figure 2 Microneutralization assay of MEDI-493 and RSV in- travenous immune globulin (IVIG) using clinical isolates of RSV.
O = MEDI-493; = RSV IVIG; A ^ no antibody added.
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus
PK
Figure 3 Single-dose serum pharmacokinetics and lung bio-distribution of palivizumab, AFFF and A4b4 in cotton rats.
Antibodies at 3 mg/kg were administered by i.m. injection. Animals were bled retro-orbitally at various times after antibody infusion, and serum human IgG titers were measured by ELISA.
Development of Motavizumab, an Ultra-potent Antibody for the Prevention of Respiratory Syncytial Virus Infection in the Upper and Lower Respiratory Tract
PK
Figure 4 Pharmacokinetics of palivizumab, A4b4, A4b4-F52S (shown as F52S) and 493L1FR-S29R (motavizumab) in cynomolgus monkeys.
A single dose at 30 mg/kg of palivizumab or its variants was administered to cynomolgus monkeys by i.v. injection.
Development of Motavizumab, an Ultra-potent Antibody for the Prevention of Respiratory Syncytial Virus Infection in the Upper and Lower Respiratory Tract
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized antibody
- Specificity
- Human Respiratory syncytial virus
- Clone
- MEDI-493
- Applications
- ELISA, Neut, PK
- Related Disease
- Respiratory syncytial virus infection
Applications
- Application Notes
- The RSV F antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization, Pharmacokinetic.
Target
- Alternative Names
- Respiratory syncytial virus; RSV; Respiratory syncytial virus fusion glycoprotein; RSV F
- Gene ID
- 1489825
- UniProt ID
- O36634
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone MEDI-493"
See other products for "RSV F"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-009 | Anti-RSV Recombinant Antibody (Palivizumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-709 | Anti-RSV glycoprotein F Recombinant Antibody (Motavizumab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| MRO-1209LC-S(P) | Anti-HRSV F Recombinant Antibody scFv Fragment (MEDI-493) | ELISA | Humanized antibody |
| MRO-1209LC-F(E) | Anti-HRSV F Recombinant Antibody Fab Fragment (MEDI-493) | ELISA | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-358CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-358CT-S(P)) | ELISA, WB, Neut, IF, FC | Human scFv |
| TAB-361CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-361CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
| TAB-362CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-362CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
| TAB-363CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-363CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
| TAB-364CT-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (TAB-364CT-S(P)) | ELISA, WB, Neut, IP | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-878LC | Human Anti-RSV F Recombinant Antibody (MRO-878LC) | ELISA, Neut | Human IgG |
| HPAB-0293CQ | Human Anti-RSV F Recombinant Antibody (HPAB-0293CQ) | ELISA, Neut, FuncS | Human IgG1 |
| PABC-494 | Recombinant Human Anti-RSV F Antibody (14N4) | SPR, ELISA, Neut | Human IgG1, κ |
| HPAB-0105-WJ | Human Anti-RSV F Recombinant Antibody (HPAB-0105-WJ) | ELISA, WB, Neut, IF, FC, Inhib, PK, IHC, DB | Human IgG |
| PABJ-0100 | Mouse Anti-RSV F Recombinant Antibody (clone R4.C6) | ELISA, Neut | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-878LC-F(E) | Human Anti-RSV F Recombinant Antibody; Fab Fragment (MRO-878LC-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0293CQ-F(E) | Human Anti-RSV F Recombinant Antibody; Fab Fragment (HPAB-0293CQ-F(E)) | ELISA, Neut | Human Fab |
| PFBC-276 | Recombinant Mouse Anti-RSV F Antibody Fab Fragment (5C4) | ELISA, Neut | Mouse Fab |
| PFBC-494 | Recombinant Human Anti-RSV F Antibody Fab Fragment (14N4) | ELISA, Neut | Human Fab |
| PABJ-0100-F(E) | Mouse Anti-RSV F Recombinant Antibody (clone R4.C6); Fab fragment | ELISA, Neut | Mouse Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1210LC | Anti-HRSV F Recombinant Antibody (C11) | ELISA | Mouse Antibody |
| MRO-1211LC | Anti-HRSV F Recombinant Antibody (C13) | ELISA | Mouse Antibody |
| MRO-1210LC-S(P) | Anti-HRSV F Recombinant Antibody scFv Fragment (C11) | ELISA | Mouse Antibody |
| MRO-1211LC-S(P) | Anti-HRSV F Recombinant Antibody scFv Fragment (C13) | ELISA | Mouse Antibody |
| MRO-1210LC-F(E) | Anti-HRSV F Recombinant Antibody Fab Fragment (C11) | ELISA | Mouse Antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0293CQ-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (HPAB-0293CQ-S(P)) | ELISA, Neut | Human scFv |
| PSBC-276 | Recombinant Mouse Anti-RSV F Antibody scFv Fragment (5C4) | ELISA, Neut | Mouse scFv |
| PSBC-494 | Recombinant Human Anti-RSV F Antibody scFv Fragment (14N4) | ELISA, Neut | Human scFv |
| HPAB-0105-WJ-S(P) | Human Anti-RSV F Recombinant Antibody; scFv Fragment (HPAB-0105-WJ-S(P)) | ELISA, WB | Human scFv |
| PABJ-0166-S(P) | Human Anti-RSV F Recombinant Antibody (clone RSD5); scFv Fragment | ELISA, Neut | Human scFv |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-009 | Afuco™ Anti-RSV F ADCC Recombinant Antibody (Palivizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-709 | Afuco™ Anti-RSV F ADCC Recombinant Antibody (Motavizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YC250 | H-2Kd/Respiratory syncytial virus Fusion protein (F) (KYKNAVTEL) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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