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Gavilimomab (TAB-156)

Recombinant monoclonal antibody to CD147. Gavilimomab (also known as ABX-CBL) is a mouse monoclonal antibody intended for use as an immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy.      

Specifications
Immunogen
Protein A-CR purified soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the hinge region, CH2-and CH3 domain of human IgG1 (CD147Rg is secreted by transfectants as a dimer).
Host
Mouse
Derivation
Mouse
Type
IgM
Specificity
Tested positive against native human antigen.
Species Reactivity
Human
Applications
Suitable for use in FuncS, IF, Neut, ELISA, FC, IP, ICC and most other immunological methods.
CAS NO.
244096-20-6
Generic Name
Gavilimomab
Related Disease
Allograft rejection
Target
Alternative Names
Gavilimomab; 244096-20-6; ABX-CBL; ABX-CBL; BSG; basigin (Ok blood group); basigin (OK blood group) , OK; basigin
Entrez Gene ID
682
UniProt ID
P35613

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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