Afuco™ Anti-BSG ADCC Recombinant Antibody (Gavilimomab), ADCC Enhanced (CAT#: AFC-TAB-156)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD147. Gavilimomab (also known as ABX-CBL) is a mouse monoclonal antibody intended for use as an immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/74870/1466_A2_3_selected.jpg
Figure 2 Testis
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_4_6.jpg
Figure 3 Heart muscle
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
(Cardiomyocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_6_6.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_B_7_5.jpg
Figure 5 Colon
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
(Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity: 75%-25% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_3.jpg
Figure 6 Kidney
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
(Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2427/6189_A_7_5.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172270-BSG
Specifications
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Gavilimomab
- Applications
- FuncS, IF, Neut, ELISA, FC, IP
- Conjugate
- Unconjugated
- Generic Name
- Gavilimomab
- Related Disease
- Allograft rejection
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Gavilimomab; 244096-20-6; ABX-CBL; ABX-CBL; BSG; basigin (Ok blood group); basigin (OK blood group), OK; basigin; CD147; EMMPRIN; CD147 antigen; OK blood group antigen; collagenase stimulatory factor; leukocyte activation antigen M6;
- Gene ID
- 682
- UniProt ID
- P35613
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Gavilimomab"
Anti-Human CD147 Recombinant Antibody (Gavilimomab)Recombinant monoclonal antibody to CD147. Gavilimomab (also known as ABX-CBL) is a mouse monoclonal antibody intended for use as an immunosuppressive biologic treatment of glucocorticoid-resistant graft versus host disease. It binds to the antigen CD147. Gavilimomab proved slightly less effective than standard antithymocyte globulin therapy.
See other products for "BSG"
Intrabody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B050(A) | Recombinant Anti-human BSG Intrabody [(D-Arg)9] | WB, ICC, Neut, FuncS | scFv-(D-Arg)9 |
| IAB-B050(G) | Recombinant Anti-human BSG Intrabody [+36 GFP] | IF, FC, FuncS | scFv-(+36GFP) |
| IAB-B050(T) | Recombinant Anti-human BSG Intrabody [Tat] | WB, ICC, FuncS | scFv-Tat |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-156 | Anti-Human CD147 Recombinant Antibody (Gavilimomab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgM |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-883 | Anti-Human CD147/BSG Recombinant Antibody (Ziralimumab) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgM |
| TAB-1289CL | Human Anti-BSG Recombinant Antibody (TAB-1289CL) | Cyt, FC | Human IgG |
| TAB-1290CL | Human Anti-BSG Recombinant Antibody (TAB-1290CL) | Cyt, FC | Human IgG |
| TAB-1285CL-S(P) | Anti-Human BSG Recombinant Antibody scFv Fragment (2.6.1 (ABX-RB2)) | Inhib | Fully human antibody |
| TAB-1287CL-S(P) | Human Anti-BSG Recombinant Antibody; scFv Fragment (TAB-1287CL-S(P)) | FC | Human scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| PSBL-461 | Mouse Anti-BSG Recombinant Antibody (clone 5F6); scFv Fragment | WB, FuncS | Mouse scFv |
| FAMAB-0033CQ-S(P) | Mouse Anti-BSG Recombinant Antibody (clone Ab-1); scFv Fragment | ELISA, Block | Mouse scFv |
| HPAB-3188LY-S(P) | Human Anti-BSG Recombinant Antibody (clone hPPAT-082-01); scfv Fragment | ELISA, FC | Humanized scfv |
| HPAB-0356-FY-S(P) | Human Anti-BSG Recombinant Antibody (clone HcHAbl8); scFv Fragment | Inhib | Humanized scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-082 | Human Anti-BSG Recombinant Antibody (clone 4A5); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| FAMAB-0033CQ-F(E) | Mouse Anti-BSG Recombinant Antibody (clone Ab-1); Fab Fragment | ELISA, Block | Mouse Fab |
| FAMAB-0034CQ-F(E) | Human Anti-BSG Recombinant Antibody (clone chAb-1); Fab Fragment | ELISA, Block | Chimeric (mouse/human) Fab |
| HPAB-0126CQ-F(E) | Mouse Anti-BSG Recombinant Antibody (clone HAb18); Fab Fragment | ELISA, IF | Mouse Fab |
| HPAB-0356-FY-F(E) | Human Anti-BSG Recombinant Antibody (clone HcHAbl8); Fab Fragment | Inhib | Humanized Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-464 | Human Anti-BSG Recombinant Antibody (clone 5F6) | WB, FuncS | Chimeric (mouse/human) IgG |
| MRO-1735-CN | Rabbit Anti-BSG Polyclonal Antibody (MRO-1735-CN) | WB, IF, IHC, FC | Rabbit IgG |
| FN-066CQ | Mouse Anti-BSG Recombinant Antibody (clone UM-8D6) | FC, FuncS, IP, WB | Mouse IgG1 |
| VS3-FY168 | Recombinant Rabbit Anti-Bsg Antibody (clone R03-7C3) | WB, ICC, IF, IP | Rabbit IgG |
| VS3-FY169 | Recombinant Rabbit Anti-BSG Antibody (clone R04-5B3) | WB, IHC-F, IHC-P, ICC, IF | Rabbit IgG |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-070CQ | Human Anti-BSG Recombinant Antibody (clone Ab-1) | ELISA, Block | Human IgG1, κ |
| NEUT-071CQ | Mouse Anti-BSG Recombinant Antibody (clone HIM6) | FC, WB, IHC, Block | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0389 | Hi-Affi™ Rabbit Anti-BSG Recombinant Antibody (clone DS389AB) | ICC, IHC-P, WB | Rabbit IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-020CN | Mouse Anti-BSG Recombinant Antibody (clone 5F6) | ELISA, Block, FuncS | Mouse IgG1 |
| NS-020CN-F(E) | Mouse Anti-BSG Recombinant Antibody (clone 5F6); Fab Fragment | ELISA | Mouse Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-883 | Afuco™ Anti-BSG ADCC Recombinant Antibody (Ziralimumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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