Afuco™ Anti-IL6 ADCC Recombinant Antibody (Sirukumab), ADCC Enhanced (CAT#: AFC-TAB-097)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL6. Sirukumab (CNTO 136) is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/72821/1350_G7_3_selected.jpg
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
(Immunohistochemical staining of human duodenum shows distinct cytoplasmic positivity in subsets of immune cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_8_2_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_B_7_5.jpg
Figure 4 Urinary bladder
(Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
(Urothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_4_5.jpg
Figure 5 Lymph node
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23406/54890_A_9_8.jpg
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, GAMG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000136244-IL6
Specifications
- Immunogen
- Recombinant full length protein (Human).
- Host Species
- Human
- Derivation
- Human
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Clone
- Sirukumab
- Applications
- FC, IP, ELISA, Neut, FuncS, IF
- Conjugate
- Unconjugated
- Generic Name
- Sirukumab
- Related Disease
- Rheumatoid arthritis (RA) (Despite Methotrexate Therapy)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Sirukumab; 1194585-53-9; CNTO 136; AME-19A; IL6; interleukin 6 (interferon, beta 2); IFNB2; interleukin-6; BSF2; HGF; HSF; IL 6; CDF; BSF-2; IFN-beta-2; interferon beta-2; interleukin BSF-2; hybridoma growth factor; CTL differentiation factor; B-cell stimulatory factor 2;
- Gene ID
- 3569
- UniProt ID
- P05231
Related Resources
Please refer to Sirukumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Sirukumab.
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Graft-versus-Host Disease
AGE-RAGE Signaling Pathway in Diabetic Complications
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Sirukumab"
Anti-Human IL6 Recombinant Antibody (Sirukumab)Recombinant monoclonal antibody to IL6. Sirukumab (CNTO 136) is a human monoclonal antibody designed for the treatment of rheumatoid arthritis.
See other products for "IL6"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-097 | Anti-Human IL6 Recombinant Antibody (Sirukumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - kappa |
| TAB-0174CL | Human Anti-IL6 Recombinant Antibody (TAB-0174CL) | ELISA, Block, In vivo | Human IgG |
| TAB-0174CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0174CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-0175CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0175CL-S(P)) | ELISA, Block, In vivo | Human scFv |
| TAB-0176CL-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0176CL-S(P)) | ELISA, Block, In vivo | Human scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-613 | Recombinant Human Anti-IL-6 Antibody scFv Fragment | ELISA, Neut | scFv |
| HPAB-0824-CN-S(P) | Human Anti-IL6 Recombinant Antibody (clone Ab18); scFv Fragment | ELISA | Human scFv |
| HPAB-0825-CN-S(P) | Human Anti-IL6 Recombinant Antibody (clone 18E); scFv Fragment | ELISA | Human scFv |
| HPAB-S0076-YC-S(P) | Rabbit Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-S0076-YC-S(P)) | ELISA, WB, Block, FuncS | Rabbit scFv |
| HPAB-S0077-YC-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-S0077-YC-S(P)) | ELISA, Block | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0022CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0022CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-0023CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0023CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-0024CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0024CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-0025CL | Mouse Anti-IL6 Recombinant Antibody (TAB-0025CL) | Elisa, In vivo, FuncS, Block | Mouse IgG |
| TAB-673LC-S(P) | Anti-human IL6 scFv Fragment | ELISA, FC |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0026CL-S(P) | Mouse Anti-IL6 Recombinant Antibody; scFv Fragment (TAB-0026CL-S(P)) | Elisa, In vivo, FuncS, Block | Mouse scFv |
| TAB-0026CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0026CL-F(E)) | Elisa, In vivo, FuncS, Block | Chimeric (mouse/human) Fab |
| TAB-670LC-S(P) | Anti-human IL6 scFv Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
| TAB-670LC-F(E) | Anti-human IL6 Fab Fragment (NTS) | ELISA | Chimeric antibody (mouse/human) |
| VS3-WK1519 | Human Anti-IL6 Recombinant Antibody (clone CLLB8) | ELISA, FC | Chimeric (mouse/human) IgG1 |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0172CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0172CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
| TAB-0173CL-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (TAB-0173CL-F(E)) | ELISA, Block, In vivo | Humanized Fab |
| TAB-678LC | Anti-human IL6 Recombinant Antibody (BA399) (TAB-678LC) | ELISA, FC, Inhib | Humanized antibody |
| TAB-678LC-S(P) | Anti-human IL6 scFv Fragment (BA399) | ELISA, FC | Humanized antibody |
| TAB-678LC-F(E) | Anti-human IL6 Fab Fragment (BA399) | ELISA, FC | Humanized antibody |
Fab Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-037LC | Recombinant Anti-Human IL6 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
Deglycosylated Antibody (Non-glycosylated IgGs)
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-197LC | Recombinant Anti-Human IL6 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0284MZ | Chicken Anti-Interleukin-6 Polyclonal IgY | WB, Indirect ELISA | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1467CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL260), FITC | FC, Neut | Mouse IgG1 |
| NEUT-1468CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL414) | WB, IHC, ELISA, Neut | Mouse IgG1 |
| NEUT-1469CQ | Rat Anti-IL6 Recombinant Antibody (clone CBL888) | ELISA, FC, IF, IP, Neut, WB | Rat IgG1, κ |
| NEUT-1470CQ | Mouse Anti-IL6 Recombinant Antibody (clone MK23) | Neut | Mouse IgG1 |
| NEUT-1471CQ | Mouse Anti-IL6 Recombinant Antibody (clone CBL713) | ICC, ICFC, Neut | Mouse IgG2b |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1474CQ | Rat Anti-Il6 Recombinant Antibody (clone 32C11) | Block, ELISA, WB | Rat IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1814 | Rabbit Anti-IL6 Recombinant Antibody (clone DS1814AB) | WB | Rabbit IgG |
| MOR-4277 | Rabbit Anti-IL6 Recombinant Antibody (clone SI360DS) | ELISA | Rabbit IgG |
| MOR-4622 | Rabbit Anti-IL6 Recombinant Antibody (clone TH135DS) | WB, ELISA | Rabbit IgG |
| MOR-4623 | Rabbit Anti-IL6 Recombinant Antibody (clone TH136DS) | WB | Rabbit IgG |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3429 | PE-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM | |
| MHC-LC3430 | APC-B8/Human IL6 (ILKQKIALD) MHC Tetramer | FCM |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-043CN | Human Anti-IL6 Recombinant Antibody (NS-043CN) | ELISA, WB | Human IgG1 |
| NS-043CN-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (NS-043CN-F(E)) | ELISA, WB | Human Fab |
| NS-043CN-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (NS-043CN-S(P)) | ELISA, WB | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0674-CN-F(E) | Human Anti-IL6 Recombinant Antibody (clone 9C8-N68T-T83S); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0030LY-F(E) | Humanized Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-0030LY-F(E)) | WB | Fab |
| HPAB-588-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-588-FY-F(E)) | ELISA | Human Fab |
| HPAB-591-FY-F(E) | Human Anti-IL6 Recombinant Antibody; Fab Fragment (HPAB-591-FY-F(E)) | ELISA | Human Fab |
| HPAB-0876-FY-S(P) | Human Anti-IL6 Recombinant Antibody; scFv Fragment (HPAB-0876-FY-S(P)) | ELISA | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0030LY | Humanized Anti-IL6 Recombinant Antibody (HPAB-0030LY) | WB | Humanized IgG4 |
| HPAB-588-FY | Human Anti-IL6 Recombinant Antibody (HPAB-588-FY) | FC, ELISA | Human IgG2 |
| HPAB-591-FY | Human Anti-IL6 Recombinant Antibody (HPAB-591-FY) | Inhib | Human IgG1 |
| HPAB-0164-YJ | Mouse Anti-IL6 Recombinant Antibody (clone 6yl-9) | ELISA, WB, Inhib, Neut | Mouse IgG1, κ |
| HPAB-0876-FY | Human Anti-IL6 Recombinant Antibody (HPAB-0876-FY) | ELISA | Human IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-239 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Elsilimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-H26 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Enlimomab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-253 | Afuco™ Anti-IL6 ADCC Recombinant Antibody (Olokizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0166-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 6D5) | ELISA | Camelid VHH |
| HPAB-S0167-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 8F2) | ELISA | Camelid VHH |
| HPAB-S0168-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 6B12) | ELISA, Inhib | Camelid VHH |
| HPAB-S0169-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 7G4) | ELISA, Inhib | Camelid VHH |
| HPAB-S0170-YC | Camelid Anti-IL6 Recombinant Single Domain Antibody (clone 7G5) | ELISA, Inhib | Camelid VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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