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Anti-IL-1RAP (interleukin-1 receptor accessory protein) Therapeutic Antibody (81.2) (TAB-221CT)

Recombinant monoclonal antibody to interleukin-1 receptor accessory protein. 81.2 is an antibody intended for the prophylaxis and treatment of solid tumours.      

Specifications
Immunogen
Fusion protein consisting of the extra cellular part of IL1RAP and the Fc-part of human lgG1
Host
Mouse
Specificity
Human
Species Reactivity
Human
Clone
81.2
Applications
Used for immunoassay techniques such as: Flow Cytometry; Enzyme-linked Immunosorbent Assay
Related Disease
Solid tumours
Target
Alternative Names
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
Entrez Gene ID
3556
UniProt ID
Q9NPH3

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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