Recombinant Humanized monoclonal antibody expressed in CHO binding to Human MMP9. GS-5745 is a monoclonal antibody that inhibits matrix metalloproteinase 9 (MMP9), an extracellular enzyme involved in matrix remodeling, tumor growth, and metastasis. Inhibiting MMP9 is expected to block paracrine signaling and metastasis and to alter the immune environment within the tumor. Preliminary safety data demonstrate a manageable safety profile for GS-5745 alone and in combination with chemotherapy. The study has been expanded to enroll additional subjects with pancreatic and esophagogastric cancer to identify potential pharmacodynamic and predictive biomarkers of response.
Figure 1 Activation of pro-MMP9 by MMP3 was measured by incubating a fixed concentration pro-MMP9 with MMP3 (0.25 ng/μl) in the presence of GS-5745 (30 ng/μl).
Reactions were incubated at 37°С for the indicated time and pro and active MMP9 were visualized by immunoblot analysis using an anti-MMP9 antibody.
Appleby, T. C., Greenstein, A. E., Hung, M., Liclican, A., Velasquez, M., Villaseñor, A. G., ... & Schultz, B. E. (2017). Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9. Journal of Biological Chemistry, 292(16), 6810-6820.
Figure 2 Inhibition of MMP9 by GS-5745.
Inhibition of activated MMP9 by GS-5745 was measured by incubating a fixed concentration of active MMP9 with various concentrations of GS-5745.
Appleby, T. C., Greenstein, A. E., Hung, M., Liclican, A., Velasquez, M., Villaseñor, A. G., ... & Schultz, B. E. (2017). Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9. Journal of Biological Chemistry, 292(16), 6810-6820.
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CAT | Product Name | Application | Type |
---|---|---|---|
DrMAB-1048 | Recombinant Mouse Anti-Human MMP9 Antibody Fab Fragment | LMNX, ELISA, WB, IF | Fab |
HPAB-0199-FY-F(E) | Human Anti-MMP9 Recombinant Antibody (clone DX-2802); Fab Fragment | ELISA, FC | Human Fab, λ |
HPAB-0200-FY-F(E) | Human Anti-MMP9 Recombinant Antibody (clone M0279-A03); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0513LY-F(E) | Mouse Anti-MMP9 Recombinant Antibody (clone M4); Fab Fragment | FC | Mouse Fab |
HPAB-0514LY-F(E) | Mouse Anti-MMP9 Recombinant Antibody (clone M12); Fab Fragment | FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0824CL | Human Anti-MMP9 Recombinant Antibody (TAB-0824CL) | ELISA | Human IgG4 |
TAB-0824CL-S(P) | Human Anti-MMP9 Recombinant Antibody; scFv Fragment (TAB-0824CL-S(P)) | ELISA | Human scFv |
TAB-0825CL-S(P) | Human Anti-MMP9 Recombinant Antibody; scFv Fragment (TAB-0825CL-S(P)) | ELISA | Human scFv |
TAB-0824CL-F(E) | Human Anti-MMP9 Recombinant Antibody; Fab Fragment (TAB-0824CL-F(E)) | ELISA | Human Fab |
TAB-0825CL-F(E) | Human Anti-MMP9 Recombinant Antibody; Fab Fragment (TAB-0825CL-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0826CL | Mouse Anti-MMP9 Recombinant Antibody (TAB-0826CL) | Inhib, ELISA, IHC | Mouse IgG |
TAB-0826CL-S(P) | Mouse Anti-MMP9 Recombinant Antibody; scFv Fragment (TAB-0826CL-S(P)) | ELISA | Mouse scFv |
TAB-0827CL-S(P) | Mouse Anti-MMP9 Recombinant Antibody; scFv Fragment (TAB-0827CL-S(P)) | ELISA | Mouse scFv |
TAB-0826CL-F(E) | Mouse Anti-MMP9 Recombinant Antibody; Fab Fragment (TAB-0826CL-F(E)) | ELISA | Mouse Fab |
TAB-0827CL-F(E) | Mouse Anti-MMP9 Recombinant Antibody; Fab Fragment (TAB-0827CL-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0717MZ | Chicken Anti-MMP9 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1748CQ | Recombinant Mouse Anti-MMP9 Antibody (VMC204) | Inhib, IHC-Fr, IP, IHC-P, WB, IHC, ICC | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2263 | Hi-Affi™ Recombinant Rabbit Anti-MMP9 Monoclonal Antibody (DS2263AB) | FC, IHC-P, WB | IgG |
MOR-4331 | Hi-Affi™ Recombinant Rabbit Anti-MMP-9 Monoclonal Antibody (SI420DS) | ELISA | IgG |
MOR-4332 | Hi-Affi™ Recombinant Rabbit Anti-MMP-9 Monoclonal Antibody (SI421DS) | ELISA | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-002ML | Anti-Human MMP9 Recombinant Antibody (Andecaliximab) | ELISA, IHC, FC, IP, IF, FuncS | IgG4, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0027-YC-S(P) | Mouse Anti-MMP9 Recombinant Antibody; scFv Fragment (HPAB-0027-YC-S(P)) | FC | Mouse scFv |
HPAB-0513LY-S(P) | Mouse Anti-MMP9 Recombinant Antibody (clone M4); scfv Fragment | FC | Mouse scfv |
HPAB-0514LY-S(P) | Mouse Anti-MMP9 Recombinant Antibody (clone M12); scfv Fragment | FC | Mouse scfv |
HPAB-M0311-YC-S(P) | Mouse Anti-MMP9 Recombinant Antibody (clone AB0046); scFv Fragment | ELISA | Mouse scFv |
HPAB-M0359-YC-S(P) | Human Anti-MMP9 Recombinant Antibody (clone AB0045); scFv Fragment | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0199-FY | Human Anti-MMP9 Recombinant Antibody (clone DX-2802) | ELISA, FC | Human IgG1, λ |
HPAB-0200-FY | Human Anti-MMP9 Recombinant Antibody (clone M0279-A03) | ELISA, FC | Human IgG |
HPAB-M0311-YC | Mouse Anti-MMP9 Recombinant Antibody (clone AB0046) | ELISA, FuncS | Mouse IgG1, κ |
VS-0522-LC77 | Mouse Anti-MMP9 Recombinant Antibody (VS-0522-LC77) | WB, IF, IHC | Mouse IgG2a |
VS-0522-LC78 | Rat Anti-MMP9 Recombinant Antibody (VS-0522-LC78) | WB, IF, IHC | Rat IgG2b |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-002ML | Afuco™ Anti-MMP9 ADCC Recombinant Antibody (Andecaliximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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