anti-NCAM1 immunotoxin N901 (IgG)-RTA (AGTO-L037R)
This immunotoxin was achieved by conjugating/fusing the Anti-NCAM1 monoclonal antibody to ricin A chain. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to small-cell lung cancer (SCLC) cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of small-cell lung cancer (SCLC).
- Species Reactivity
- Molecule Class
- L kappa; IgG1-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Small-cell lung cancer (SCLC)
- Alternative Names
- NCAM1; neural cell adhesion molecule 1; CD56; NCAM; MSK39; neural cell adhesion molecule, NCAM; antigen recognized by monoclonal antibody 5.1H11; Small-cell lung cancer
- Entrez Gene ID
- UniProt ID
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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