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Anti-NUP88 Intrabody [Tat] (IAB-B063(T))

Recombinant anti-NUP88 intrabody in fusion with HIV Tat works within cells to bind the nuclear pore protein NUP88, expressed in E. coli cells. Anti-Nup88 intrabody, an anti-sense oligonucleotide or nucleic acid which is complementary to at least a functional part of a Nup88 RNA or wherein the compound is a peptide, peptide-like or non-peptide Nup88 inhibitor which can be identified by contacting the compound or libraries of peptido- mimetics, peptides, DNA or cDNA expression, combinatorial chemistry or phage display with substantially purified Nup88, fragments thereof or structural analogues thereof.      

Specifications
Immunogen
human nucleoporin 88kDa
Host
rabbit
Type
scFv-Tat
Cell Penetrating Peptide
TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
Species Reactivity
human
Applications
Antibody assay: Enzyme-linked Immunosorbent Assay; Immunofluorescence; Neutralization; Functional studies
Target
Alternative Names
NUP88; nucleoporin 88kDa; nuclear pore complex protein Nup88; karyoporin; nucleoporin 88kD; nucleoporin Nup88; 88 kDa nucleoporin; nuclear pore complex protein 88
Entrez Gene ID
4927
UniProt ID
Q99567

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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