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Anti-PREV Intrabody [(D-Arg)9] (IAB-B007(A))

Recombinant anti-PREV intrabody linked to (D-Arg)9 works within cells to bind secifically to a retrovirus protein PREV particle protein, expressed in 293T cells. Intracellular antibody which disrupts the catalysis of the production of the xenoantigen galactose α 1,3 galactose and/or a polynucleotide construct which encodes an intracellular antibody which binds specifically to a retrovirus protein, such as a PERV particle protein.      

Specifications
Immunogen
porcine retroviruses
Host
llama
Type
vhh-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
PERV
Applications
Used for immunoassay techniques such as: Fluorescence-activated cell sorting; Immunocytochemistry; Functional studies
Target
Alternative Names
PREV; porcine retroviruses

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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