Recombinant Mouse Anti-RSV F Antibody (101F) (CAT#: PABC-209)
Recombinant Mouse Antibody (101F) is capable of binding to RSV F, expressed in Chinese Hamster Ovary cells (CHO). 101F can bind to multiple conformations of the fusion glycoprotein and can neutralize late in the entry process. The structural preservation of neutralizing epitopes in the postfusion state suggests that this conformation can elicit neutralizing antibodies and serve as a useful vaccine antigen.
Specific Inquiry
ELISA
Figure 1 mAb 101F ELISA binding.
ELISA binding of mAb 101F to the indicated postfusion proteins.
Mas, V., Rodriguez, L., Olmedillas, E., Cano, O., Palomo, C., Terron, M. C., ... & McLellan, J. S. (2016). Engineering, structure and immunogenicity of the human metapneumovirus F protein in the postfusion conformation. PLoS pathogens, 12(9).
Neut
Figure 2 mAb 101F neutralization.
Neutralization of the noted viruseswith the three mAbs.
Mas, V., Rodriguez, L., Olmedillas, E., Cano, O., Palomo, C., Terron, M. C., ... & McLellan, J. S. (2016). Engineering, structure and immunogenicity of the human metapneumovirus F protein in the postfusion conformation. PLoS pathogens, 12(9).
IF
Figure 3 Structural basis of 101F cross-reactivity.
Negatively stained electron micrographs of 101F Fab bound to postfusion hRSV F.
Mas, V., Rodriguez, L., Olmedillas, E., Cano, O., Palomo, C., Terron, M. C., ... & McLellan, J. S. (2016). Engineering, structure and immunogenicity of the human metapneumovirus F protein in the postfusion conformation. PLoS pathogens, 12(9).
Specifications
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- IgG
- Specificity
- Tested positive against native RSV F
- Species Reactivity
- RSV
- Clone
- 101F
- Applications
- ELISA, Neut, IF
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-Linked Immunosorbent Assay, Neutralization and Immunofluorescence.
Target
- Alternative Names
- RSV; F; Fusion protein (F)
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 101F"
See other products for "F"
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-687 | Recombinant Mouse Anti-RSV gp F Antibody Fab Fragment (101F) | ELISA, Neut | Fab |
| PSBC-209 | Recombinant Mouse Anti-RSV F Antibody scFv Fragment (101F) | Neut | scFv |
| HPAB-0139-YJ-F(E) | Mouse Anti-F Recombinant Antibody; Fab Fragment (HPAB-0139-YJ-F(E)) | Neut, Inhib, WB, IP | Mouse Fab |
| HPAB-0140-YJ-F(E) | Human Anti-F Recombinant Antibody; Fab Fragment (HPAB-0140-YJ-F(E)) | Neut, Inhib, WB, IP | Human Fab |
| HPAB-0141-YJ-F(E) | Human Anti-F Recombinant Antibody; Fab Fragment (HPAB-0141-YJ-F(E)) | Neut, Inhib, WB, IP | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-215 | Recombinant Human Anti-RSV F Antibody (B21m) | Neut | IgG |
| MOB-1230CT | Recombinant Mouse anti-Other F Monoclonal antibody (iNQW 35) | ELISA, ICC/IF | |
| HPAB-0139-YJ | Mouse Anti-F Recombinant Antibody (HPAB-0139-YJ) | Neut, Inhib, WB, IP | Mouse IgG1, κ |
| HPAB-0140-YJ | Human Anti-F Recombinant Antibody (HPAB-0140-YJ) | Neut, Inhib, WB, IP | Human IgG1, κ |
| HPAB-0141-YJ | Human Anti-F Recombinant Antibody (HPAB-0141-YJ) | Neut, Inhib, WB, IP | Human IgG1, κ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-209 | Recombinant Mouse Anti-RSV F Antibody Fab Fragment (101F) | Neut | Fab |
| PFBC-215 | Recombinant Human Anti-RSV F Antibody Fab Fragment (B21m) | Neut | Fab |
| HPAB-0139-YJ-S(P) | Mouse Anti-F Recombinant Antibody; scFv Fragment (HPAB-0139-YJ-S(P)) | Neut, Inhib, WB, IP | Mouse scFv |
| HPAB-0140-YJ-S(P) | Human Anti-F Recombinant Antibody; scFv Fragment (HPAB-0140-YJ-S(P)) | Neut, Inhib, WB, IP | Human scFv |
| HPAB-0141-YJ-S(P) | Human Anti-F Recombinant Antibody; scFv Fragment (HPAB-0141-YJ-S(P)) | Neut, Inhib, WB, IP | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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