Products

Anti-TAL6 Immunocytokine, scFv (L6)-FasL (ACFP-SH151)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-TAL6 scFv to FasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the TAL6 as well as the biological activity of FasL. This antibody-cytokine fusion protein is highly effective in in vitro killing of human TAG-72+ Jurkat-Ras tumor cells with a 500-fold greater cytotoxicity as compared to soluble FasL (sFasL). ScFv-FasLext with a strong cytotoxicity against sensitive human tumor targets may be useful as effective chemotherapeutic agents. This immunocytokine was designed for treating carcinomas of the breast, colon, lung, and ovary.      

Specifications
Target
TAL6
Molecule Class
scFv-FasL
Species Reactivity
Human
Host
Chimeric (Human-Mouse)
Expression Host
CHO
Clone
L6
Related Disease
Carcinomas of the breast, colon, lung, and ovary
Cytokines 1
FasL
Cytokines 1 Description
Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TM4SF1; transmembrane 4 L six family member 1; L6; H-L6; M3S1; TAAL6; transmembrane 4 L6 family member 1; tumor-associated antigen L6
Entrez Gene ID
4071
UniProt ID
P30408

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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