CD4-RTA immunotoxin (AGTO-L021R)
This immunotoxin was achieved by conjugating/fusing the CD4 to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells infected with HIV. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of AIDS.
- Species Reactivity
- Molecule Class
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Alternative Names
- HIV; human immunodeficiency virus; ADIS; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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