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Anti-CD37 (K7153A)-SMCC-DM1 ADC (CAT#: ADC-064LCT)

This ADC product is composed of an anti-CD37 antibody (clone K7153A) conjuagated via a SMCC linker to DM1 (K7153A-SMCC-DM1). It has demonstrated a response in Relapsed or refractory nonHodgkin's lymphoma treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HEL
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/1848_F10_26_cr5abb8def07051_selected.jpg
Normal Tissue
Figure 2 Tonsil
Figure 2 Tonsil
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_A_5_8_val_selected.jpg
Figure 3 Colon
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_9_3.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2492/6132_A_7_8.jpg
Figure 5 Spleen
Figure 5 Spleen
(Cells in white pulp Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/32120/116092_B_8_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HMC-1, RPMI-8226, THP-1, U-698, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104894-CD37

Specifications

  • Antibody Overview
  • Humanized IgG1 Antibody K7153A (Anti-CD37)
  • Clone
  • K7153A
  • Antibody Isotype
  • IgG1
  • Linker
  • SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
  • Linker Class/Description
  • Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD37; CD37 molecule; GP52-40; TSPAN26; leukocyte antigen CD37; tspan-26; tetraspanin-26; leukocyte surface antigen CD37; cell differentiation antigen 37;

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Humanized Antibody

CAT Product Name Application Type
TAB-904 Anti-Human CD37 Recombinant Antibody (Otlertuzumab) ELISA, IP, FC, FuncS, Neut, IF, ICC VH - V-kappa - CH2 - CH3

Chimeric Antibody

CAT Product Name Application Type
TAB-0272CL Anti-Human CD37 Recombinant Antibody (chHH1.1,) ELISA, WB Chimeric (mouse/human)
TAB-0273CL Anti-Human CD37 Recombinant Antibody (chHH1.3) Block Chimeric (mouse/human)
TAB-0272CL-S(P) Anti-Human CD37 Recombinant Antibody scFv Fragment (chHH1.1,) ELISA, WB Chimeric (mouse/human)
TAB-0272CL-F(E) Anti-Human CD37 Recombinant Antibody Fab Fragment (chHH1.1,) ELISA, WB Chimeric (mouse/human)
TAB-0273CL-F(E) Anti-Human CD37 Recombinant Antibody Fab Fragment (chHH1.3) Block Chimeric (mouse/human)

Mouse Antibody

CAT Product Name Application Type
TAB-467CQ Anti-Human CD37 Recombinant Antibody (Lilotomab) ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0159-FY-S(P) Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0159-FY-S(P)) Activ, Depletion, FuncS, Inhib Mouse scFv
HPAB-0163-FY-S(P) Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0163-FY-S(P)) FC, Inhib Mouse scFv
HPAB-0164-FY-S(P) Mouse Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-0164-FY-S(P)) FC, Inhib Mouse scFv
HPAB-AP033-YC-S(P) Human Anti-CD37 Recombinant Antibody (clone A2); scFv Fragment FuncS Human scFv
HPAB-0901-WJ-S(P) Mouse Anti-CD37 Recombinant Antibody (clone HH1); scFv Fragment FC Mouse scFv

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-467CQ Afuco™ Anti-CD37 ADCC Recombinant Antibody (Lilotomab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-AP033-YC-F(E) Human Anti-CD37 Recombinant Antibody (clone A2); Fab Fragment FuncS Human Fab
HPAB-AP034-YC-F(E) Human Anti-CD37 Recombinant Antibody (clone B2); Fab Fragment FuncS Human Fab
HPAB-1045-FY-S(P) Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1045-FY-S(P)) FC, ELISA Human scFv
HPAB-1046-FY-S(P) Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1046-FY-S(P)) FC, ELISA Human scFv
HPAB-1047-FY-S(P) Human Anti-CD37 Recombinant Antibody; scFv Fragment (HPAB-1047-FY-S(P)) FC, ELISA Human scFv

Recombinant Antibody

CAT Product Name Application Type
HPAB-0901-WJ Mouse Anti-CD37 Recombinant Antibody (clone HH1) FC Human IgG
HPAB-0004-SJF Mouse Anti-CD37 Recombinant Antibody (HPAB-0004-SJF) ELISA, IHC, FuncS Mouse IgG
HPAB-0006-SJF Mouse Anti-CD37 Recombinant Antibody (clone A0) FACS, FuncS Mouse IgG
HPAB-0009-SJF Human Anti-CD37 Recombinant Antibody (clone CAS-024) FuncS Humanized IgG1
FAMAB-1051CQ Human Anti-CD37 Recombinant Antibody (clone G28-1) Depletion Human IgG1

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