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Kunitz domains anti-VEGFA (SKD-L100)

The Kunitz domain that bound VEGFA was isolated from the library using phage display techonology. Kunitz domains are stable as standalone peptides, able to recognise specific protein structures, and also work as competitive protease inhibitors in their free form. After affinity maturation, Kunitz domains variants were identified having affinities (KD=500 nM) for VEGFA as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Specifications
Scaffold Name
Kunitz domains
Origin
BPTI
Core Structure
α-helices, β-sheets
Variable Regions
1–2 Loops
Target
VEGFA
Species Reactivity
Human
Expression Host
E. coli
Affinity Constant
500 nM
Applications
ELISA; IHC; Microscopy; FC; WB; FuncS
Target
Alternative Names
BPTI; Kunitz domains; VPF; VEGF; MVCD1
Entrez Gene ID
7422
UniProt ID
P15692

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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