Human Anti-VEGFA Recombinant Antibody (clone FD006) (CAT#: HPAB-0114-WJ)
This product is a humanized IgG antibody targeting human vascular endothelial growth factor (VEGF). This antibody has a good biological activity and can inhibit cell proliferation of vascular endothelial cells, obviously inhibit tumor growth, and effectively inhibit the growth of corneal neovascularization, and can be used for preparing targeted medicines of specific targeting VEGF antigens or angiogenesis inhibiting medicines.
Specific Inquiry
ELISA
Figure 1 Antigen binding identification of FD006 to bind VEGF.
(A) The binding activity of FD006 by ELISA.
Wang, Q., Yang, J., Tang, K., Luo, L., Wang, L., Tian, L., ... & Lv, M. (2014). Pharmacological characteristics and efficacy of a novel anti-angiogenic antibody FD006 in corneal neovascularization. BMC biotechnology, 14(1), 17.
IHC
Figure 2 Hematoxylin and eosin (HE) staining observation of corneas.
At day 7, corneal neovascularization of various sizes (black arrowhead) were present in the superficial central corneal stroma after alkali burn (×200) and neovascularization containing RBCs in the corneal stroma were indicated with black arrowheads. Cornea stroma exhibited edema and mononuclear inflammatory response. In this plane of section, the corneal epithelium is relatively normal. Bar = 100 μm.
Wang, Q., Yang, J., Tang, K., Luo, L., Wang, L., Tian, L., ... & Lv, M. (2014). Pharmacological characteristics and efficacy of a novel anti-angiogenic antibody FD006 in corneal neovascularization. BMC biotechnology, 14(1), 17.
WB
Figure 3 The protein expression of neovascularization-related signal molecules in the cornea.
β-actin served as an internal standard. The protein expression of VEGF, MMP-9, VEGFR-1, VEGFR-2 and ICAM-1 in the cornea was significantly weaker in antibody- or dexamethasone- treated samples.
Wang, Q., Yang, J., Tang, K., Luo, L., Wang, L., Tian, L., ... & Lv, M. (2014). Pharmacological characteristics and efficacy of a novel anti-angiogenic antibody FD006 in corneal neovascularization. BMC biotechnology, 14(1), 17.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized IgG
- Specificity
- Human VEGF
- Species Reactivity
- Human
- Clone
- FD006
- Applications
- ELISA, IHC, WB
- Related Disease
- Colorectal Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The VEGF antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Immunohistochemistry, Western Blot.
Target
- Alternative Names
- Vascular endothelial growth factor; VEGF
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone FD006"
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Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-011 | Anti-Human VEGF Recombinant Antibody (Bevacizumab) | FC, IP, ELISA, Neut, FuncS, IF, ICC | IgG1 - kappa |
| TAB-012-F(E) | Anti-Human VEGF Recombinant Antibody Fab Fragment (Ranibizumab) | IP, IF, FuncS, FC, Neut, ELISA, IHC | Fab - G1 - kappa |
| TAB-307CQ | Human Anti-VEGFA Recombinant Antibody (TAB-307CQ) | Inhib | Human IgG |
| TAB-307CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-307CQ-S(P)) | ELISA, Neut | Human scFv |
| TAB-009ML | Anti-Human VEGFA Recombinant Antibody scFv Fragment (Brolucizumab) | ELISA, IHC, FC, IP, IF, Inhib | scFv, κ |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L043L | anti-VEGFA immunotoxin Ng76 (scFv)-Luffin-β | Cytotoxicity assay, Functional assay |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-358 | Human Anti-VEGFA Recombinant Antibody (clone 5A12); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| HPAB-0004-WJ-F(E) | Human Anti-VEGFA Recombinant Antibody (clone 8B13); Fab Fragment | ELISA | Humanized Fab |
| HPAB-N0295-YC-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-N0295-YC-F(E)) | ELISA | Human Fab |
| HPAB-N0296-YC-F(E) | Human Anti-VEGFA Recombinant Antibody; Fab Fragment (HPAB-N0296-YC-F(E)) | ELISA | Human Fab |
| HPAB-0418-YJ-F(E) | Human Anti-VEGFA Recombinant Antibody (clone CBV59YJ); Fab Fragment | ELISA | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-284CQ | Human Anti-VEGFA Recombinant Antibody (TAB-284CQ) | WB | Human antibody |
| TAB-284CQ-S(P) | Human Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-284CQ-S(P)) | ELISA | Human scFv |
| TAB-304CQ-S(P) | Anti-Human VEGFA Recombinant Antibody scFv Fragment (2H1) | ELISA, WB | Human antibody |
| TAB-305CQ-S(P) | Anti-Human VEGFA Recombinant Antibody scFv Fragment (2H1-32) | ELISA, WB | Human antibody |
| TAB-465CQ | Anti-Human VEGFA Recombinant Antibody (Varisacumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-306CQ | Mouse Anti-VEGFA Recombinant Antibody (TAB-306CQ) | FuncS, Inhib | Mouse IgG |
| TAB-306CQ-S(P) | Mouse Anti-VEGFA Recombinant Antibody; scFv Fragment (TAB-306CQ-S(P)) | ELISA, Neut | Mouse scFv |
| TAB-306CQ-F(E) | Mouse Anti-VEGFA Recombinant Antibody; Fab Fragment (TAB-306CQ-F(E)) | ELISA, Neut | Mouse Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0623MZ | Chicken Anti-VEGF Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2255CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL198) | Neut, WB | Mouse IgG1 |
| NEUT-2256CQ | Rat Anti-Vegfa Recombinant Antibody (clone 2G11-2A05) | WB, Neut, ELISA, IHC, FuncS | Rat IgG2a, κ |
| NEUT-2257CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 16F1) | WB, Neut | Mouse IgG2a |
| NEUT-2258CQ | Mouse Anti-VEGFA Recombinant Antibody (clone 4B2-8) | ELISA, Neut, WB | Mouse IgG1, κ |
| NEUT-2260CQ | Mouse Anti-VEGFA Recombinant Antibody (clone CBL737) | WB, ELISA, Neut | Mouse IgG2b |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2259CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A.4.6.1) | ELISA, IP, WB, Block, FC, IHC | Mouse IgG1, κ |
| NEUT-2267CQ | Mouse Anti-VEGFA Recombinant Antibody (clone A15136B) | WB, Block | Mouse IgG2b, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3835 | Rabbit Anti-VEGFA Recombinant Antibody (clone DS3835AB) | FC, ICC, IF, IHC-P, IP, WB | Rabbit IgG |
| MOR-4758 | Rabbit Anti-Vegfa Recombinant Antibody (clone TH272DS) | WB | Rabbit IgG |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MD-ZBF-YC024 | Camelid Anti-VEGFA Recombinant Single Domain Antibody (clone A80887) | ELlSA | Camelid VHH |
| HPAB-N0310-YC-VHNAR | Recombinant Shark Anti-VEGFA Single Domain Antibody (V32R) | ELISA, FC, WB | Shark vNAR |
| HPAB-0337-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (V32R) | FC, ELISA, Inhib, Neut | Shark vNAR |
| HPAB-0338-YJ-vNAR | Recombinant Shark Anti-VEGFA vNAR (V19) | FC, ELISA, Inhib, Neut | Shark vNAR |
| NBD-0090-YJ-VHH | Camelid Anti-VEGFA Recombinant Single Domain Antibody (Nb42) | ELISA, WB, Inhib | Camelid VHH |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-465CQ | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Varisacumab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-011 | Afuco™ Anti-VEGFA ADCC Recombinant Antibody (Bevacizumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0242-YC | Human Anti-VEGFA Recombinant Antibody (clone B5E3) | ELISA | Humanized IgG |
| HPAB-M0243-YC | Human Anti-VEGFA Recombinant Antibody (clone Bev-B5E3BsAb) | ELISA, Block, Inhib | Humanized IgG |
| HPAB-0060-YJ | Mouse Anti-VEGFA Recombinant Antibody (clone 2C3) | FuncS, IHC, WB, Block, ELISA, IP | Mouse IgG2a, κ |
| HPAB-0336-YJ | Human Anti-VEGFA Recombinant Antibody (clone BAT-1706) | FuncS | Humanized IgG1 |
| HPAB-2044-FY | Human Anti-VEGFA Recombinant Antibody (clone c870) | IA | Human IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0715-FY-F(E) | Mouse Anti-VEGFA Recombinant Antibody (clone AB014); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1625-FY-F(E) | Human Anti-VEGFA Recombinant Antibody (clone TK001); scFv Fragment | ELISA, Inhib | Humanized scFv |
| HPAB-1956-FY-S(P) | Human Anti-VEGFA Recombinant Antibody (clone Bh21-7); scFv Fragment | IF | Humanized scFv |
| HPAB-1957-FY-S(P) | Mouse Anti-VEGFA Recombinant Antibody (clone 21-7); scFv Fragment | IF | Mouse scFv |
| HPAB-0677YY-S(P) | Mouse Anti-VEGFA Recombinant Antibody (clone CBV110YJ); scFv Fragment | ELISA, FuncS | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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