Human Anti-ASTL Recombinant Antibody (clone SB2) (CAT#: HPAB-3129LY)
This product is an antibody that recognizes SAS1B. The antibody SB2 can be used for immunoassay techniques such as: ELISA, WB, IF.
Specific Inquiry
FC
Figure 1 SAS1B surface expression in pancreatic cancer cell lines correlated to anti-SAS1B ADC cell killing in vitro.
Median fluorescent intensity of cell surface SAS1B detected by live cell flow cytometry with SB2 monoclonal antibody (blue line) or unrelated control antibody (red line) on PDAC cell lines keratinocytes.
Knapp, K. A., Pires, E. S., Adair, S. J., Mandal, A., Mills, A. M., Olson, W. C., ... & Herr, J. C. (2018). Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer. Oncotarget, 9(10), 8972.
IF
Figure 2 SAS1B localized to the cytoplasm and to the cell surface in pancreatic cancer cell lines.
Fixed and permeabilized indirect immunofluorescence (IIF) using anti-SAS1B mAb, SB2 showed SAS1B localized to the cytoplasm of pancreatic cancer cell line 608 compared to normal keratinocytes.
Knapp, K. A., Pires, E. S., Adair, S. J., Mandal, A., Mills, A. M., Olson, W. C., ... & Herr, J. C. (2018). Evaluation of SAS1B as a target for antibody-drug conjugate therapy in the treatment of pancreatic cancer. Oncotarget, 9(10), 8972.
Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Human IgG2b
- Specificity
- Human ASTL
- Species Reactivity
- Human
- Clone
- SB2
- Applications
- FC, IF
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Flow Cytometry and Immunofluorescence. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. should be carefully titrated in specific assays.
Target
- Alternative Names
- Astacin Like Metalloendopeptidase; Astacin-Like Metallo-Endopeptidase (M12 Family); Sperm Acrosomal SLLP1 Binding; Oocyte Astacin; Ovastacin; Astacin-Like Metalloendopeptidase (M12 Family); Astacin-Like Metalloendopeptidase
- Gene ID
- 431705
- UniProt ID
- Q6HA08
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone SB2"
See other products for "ASTL"
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L044S | anti-ASTL immunotoxin D-8 (Fab)-Sap | Cytotoxicity assay, Functional assay |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC | Mouse Anti-ASTL Recombinant Antibody (clone 7H2) | WB, IP | Mouse IgG1, κ |
| HPAB-M0631-YC | Mouse Anti-ASTL Recombinant Antibody (clone 6C1) | WB, IP | Mouse IgG1, κ |
| HPAB-M0632-YC | Mouse Anti-ASTL Recombinant Antibody (clone 3F2) | WB, IF | Mouse IgG |
| HPAB-M0633-YC | Mouse Anti-ASTL Recombinant Antibody (clone 6B1) | IHC, IF, WB | Mouse IgG |
| HPAB-M0634-YC | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2) | WB, FC | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0634-YC-S(P) | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2); scFv Fragment | WB, FC | Rabbit scFv |
| HPAB-M0635-YC-S(P) | Rabbit Anti-ASTL Recombinant Antibody (clone 1H3/1K3); scFv Fragment | WB, FC | Rabbit scFv |
| HPAB-M0636-YC-S(P) | Rabbit Anti-ASTL Recombinant Antibody (clone 2H2/2K5); scFv Fragment | WB, FC | Rabbit scFv |
| HPAB-M0637-YC-S(P) | Rabbit Anti-ASTL Recombinant Antibody (clone 3H4/3K5); scFv Fragment | WB | Rabbit scFv |
| HPAB-M0638-YC-S(P) | Rabbit Anti-ASTL Recombinant Antibody (clone 5H2/5K1); scFv Fragment | WB | Rabbit scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0630-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 7H2); Fab Fragment | WB, IP | Mouse Fab |
| HPAB-M0631-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 6C1); Fab Fragment | WB, IP | Mouse Fab |
| HPAB-M0632-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 3F2); Fab Fragment | WB, IF | Mouse Fab |
| HPAB-M0633-YC-F(E) | Mouse Anti-ASTL Recombinant Antibody (clone 6B1); Fab Fragment | WB, IF | Mouse Fab |
| HPAB-M0634-YC-F(E) | Rabbit Anti-ASTL Recombinant Antibody (clone 1H2/1K2); Fab Fragment | WB, FC | Rabbit Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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