This product is a recombinant antibody that recognizes Anthrax PA toxin. The monoclonal antibody 1C6 reacts with the epitope of Anthrax PA toxin.
Figure 1 Determination of AVP-1C6 IC50 using RAW 264.7 264.7 cell based assay.
1.2 nM PA and 0.56 nM LF in a 96 well assay on confluent RAW 264.7 264.7 cells cause 100% cell lysis. The AVP-21D9 was assessed at various concentrations for the ability to inhibit the lethal toxin.
Sawada-Hirai, R. , Jiang, I. , Wang, F. , Sun, S. M. , & Kang, A. S. . (2004). Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed. Journal of Immune Based Therapies and Vaccines, 2(1), 5.
Figure 1 Protection of rats from a lethal toxin challenge five minutesafter administration of antibody.
Male Fisher 344 rats with jugular vein catheters weighing between 200–250 g were administered human anti-anthrax PA IgG monoclonal antibodies AVP-21D9, AVP-22G12, AVP-1C6, or the control human IgG in 0.2 ml PBS 0.1% BSA pH 7.4, 5 minutes later lethal toxin (PA 20 µg + LF 4 µg/200 g rat in 0.2 ml PBS 0.1% BSA pH 7.4) was administered.
Sawada-Hirai, R. , Jiang, I. , Wang, F. , Sun, S. M. , & Kang, A. S. . (2004). Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed. Journal of Immune Based Therapies and Vaccines, 2(1), 5.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
NAB-194-VHH | Recombinant Anti-B. anthracis PA VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-97-F(E) | Recombinant Anti-B. anthracis PA Antibody Fab Fragment | RIA, IP, FuncS | Fab |
MHH-97-F(E) | Recombinant Human Anti-B. anthracis PA Antibody Fab Fragment | ELISA, WB, FC, FuncS | Fab |
HPAB-0747-YJ-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (W1); Fab Fragment | ELISA, Neut | Chimeric (chimpanzee/human) Fab |
HPAB-0748-YJ-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (W2); Fab Fragment | ELISA, WB, Neut, FuncS | Chimeric (chimpanzee/human) Fab |
FAMAB-0333JF-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 001.46F1); Fab Fragment | ELISA, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-224 | Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab) | FC, IP, ELISA, Neut, FuncS, IF, WB | IgG1 - lambda |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-97-S(P) | Recombinant Human Anti-B. anthracis PA Antibody scFv Fragment | Neut, WB, FuncS | scFv |
HPAB-1825-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 1C6); scFv Fragment | ELISA | Human scFv |
HPAB-1826-FY-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (clone 4H7); scFv Fragment | ELISA | Human scFv |
FAMAB-0048JF-S(P) | Human Anti-B. anthracis PA Recombinant Antibody (clone 83K7C); scFv Fragment | WB, ELISA, FuncS | Human scFv |
FAMAB-0223JF-S(P) | Monkey Anti-B. anthracis PA Recombinant Antibody (clone 35PA83); scFv Fragment | ELISA, FuncS | Monkey scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
EPAF-0387LC | Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) | BL, ELISA | IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0780-CN | Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0780-CN) | ELISA, Neut | Mouse IgG1, κ |
HPAB-0781-CN | Mouse Anti-B. anthracis PA Recombinant Antibody (HPAB-0781-CN) | ELISA, Neut | Mouse IgG1, κ |
HPAB-1646-FY | Human Anti-B. anthracis PA Recombinant Antibody (HPAB-1646-FY) | Neut, ELISA, Inhib | Human IgG |
HPAB-1647-FY | Human Anti-B. anthracis PA Recombinant Antibody (HPAB-1647-FY) | Neut | Human IgG |
HPAB-1648-FY | Human Anti-B. anthracis PA Recombinant Antibody (HPAB-1648-FY) | Inhib | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-224 | Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody (Raxibacumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-440CQ | Afuco™ Anti-PA ADCC Recombinant Antibody (Obiltoxaximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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