This product is a recombinant mouse antibody that can bind to Rat CD4 with high affinity.
Figure 1 Flow cytometric analysis of blood lymphocytes 24 hours after treatment with 20 mg/kg RIB 5/2.
Demonstrated no significant change in percentage of CD4+ cells but did show a significant reduction in MCF consistent with CD4 modulation.
Motoyama, K., Arima, T., Lehmann, M., & Flye, M. W. (1997). Tolerance to heart and kidney grafts induced by nondepleting anti-CD4 monoclonal antibody (RIB 5/2) versus depleting anti-CD4 monoclonal antibody (OX-38) with donor antigen administration. Surgery, 122(2), 213-220.
Figure 2 MCF of CD4+ cells had recovered to normal levels and this time was selected for the transplant to evaluate the effects of donor specific alloantigen.
(A) Fluorescence-activated cell sorter analysis of naïve BUF splenocytes revealed 48% CD4+ T cells. (B) 24 hr after in vivo administration of 20 mg/kg mAb, RIB 5/2, the MCF of CD4 cells was markedly reduced, whereas the percentage remained essentially the same at 44%. (C) By Day 21 after administration of RIB 5/2 (20 mg/kg), the MCF of CD4 cells had recovered and represented 35% of the total BUF splenocytes.
Lehmann, M., Graser, E., Risch, K., Hancock, W. W., Müller, A., Kuttler, B.,... & Volk, H. D. (1997). ANTI-CD4 MONOCLONAL ANTIBODY-INDUCED ALLOGRAFT TOLERANCE IN RATS DESPITE PERSISTENCE OF DONOR-REACTIVE T CELLS1. Transplantation, 64(8), 1181-1187.
Figure 3 Time course of luciferase expression in lung homogenates after AdCMVLuc administration.
RIB 5/2 treatment resulted in significant prolongation of reporter gene expression in the lungs of rats. Data are presented as the mean ± SEM of luciferase activity per milligram of protein in lung homogenates over time.
LEI, D., LEHMANN, M., SHELLITO, J. E., NELSON, S., SIEGLING, A., VOLK, H. D., & KOLLS, J. K. (1996). Nondepleting anti-CD4 antibody treatment prolongs lung-directed E1-deleted adenovirus-mediated gene expression in rats. Human gene therapy, 7(18), 2273-2279.
Figure 4 Chemiluminescence of β-Gal activity in the lungs of rats 6 weeks after AdCMVβgal delivery.
Again RIB 5/2 treatment was associated with significantly greater activity of the reporter gene in lung homogenates. Naive animals received PBS intratracheally to control for background in the lung homogenate.
LEI, D., LEHMANN, M., SHELLITO, J. E., NELSON, S., SIEGLING, A., VOLK, H. D., & KOLLS, J. K. (1996). Nondepleting anti-CD4 antibody treatment prolongs lung-directed E1-deleted adenovirus-mediated gene expression in rats. Human gene therapy, 7(18), 2273-2279.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-107 | Anti-Human CD4 Recombinant Antibody (Cedelizumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG4 - kappa |
TAB-161LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (gOKT4A-4) | ELISA | Humanized antibody |
TAB-168LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (TRX1) | ELISA | Humanized antibody |
TAB-171LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-171LC-S(P)) | ELISA, SPR | Humanized scFv |
TAB-172LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-172LC-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-173LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (IgA F425-Alg8) | ELISA | |
TAB-174LC-S(P) | Mouse Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-174LC-S(P)) | ELISA, FC, IH | Mouse scFv |
TAB-175LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (15A7) | FC, ELISA | |
TAB-176LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (14G7) | FC, ELISA | |
TAB-175LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (15A7) | FC, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-162LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
TAB-164LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-164LC-F(E)) | FC, SPR, ELISA | Chimeric (macaque/human) Fab |
TAB-165LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-165LC-F(E)) | FC, SPR, ELISA | Chimeric (macaque/human) Fab |
TAB-167LC-F(E) | Anti-Human CD4 Recombinant Antibody Fab Fragment (cM-T412) | ELISA | Chimeric antibody (mouse/human) |
TAB-170LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) | ELISA, SPR | Chimeric antibody (rat/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-025LC | Recombinant Anti-Human CD4 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0758-CN | Human Anti-CD4 Recombinant Antibody (clone Variant B) | ELISA, FC | Human IgG1 |
HPAB-0759-CN | Human Anti-CD4 Recombinant Antibody (clone Variant D) | ELISA, FC | Human IgG1 |
HPAB-0792-CN | Mouse Anti-CD4 Recombinant Antibody (clone B4) | ELISA | Mouse IgG |
HPAB-0793-CN | Human Anti-CD4 Recombinant Antibody (clone chB4) | ELISA | Chimeric (mouse/human) IgG1 |
HPAB-0794-CN | Human Anti-CD4 Recombinant Antibody (clone dB4C7) | ELISA | Chimeric (mouse/human) IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0758-CN-S(P) | Human Anti-CD4 Recombinant Antibody (clone Variant B); scFv Fragment | ELISA, FC | Human scFv |
HPAB-0759-CN-S(P) | Human Anti-CD4 Recombinant Antibody (clone Variant D); scFv Fragment | ELISA, FC | Human scFv |
HPAB-2059LY-S(P) | Mouse Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-2059LY-S(P)) | FC | Mouse scfv |
HPAB-1110WJ-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone KCLRF-BP-00211); scFv Fragment | FC, IHC | Mouse scFv |
HPAB-2112-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone MT15.1); scFv Fragment | Inhib | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0295-FY-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone CBLC-005); Fab Fragment | WB, IHC, FC | Mouse Fab |
HPAB-0557-WJ-F(E) | Human Anti-CD4 Recombinant Antibody (clone TRX1); Fab Fragment | ELISA | Human Fab |
HPAB-0558-WJ-F(E) | Human Anti-CD4 Recombinant Antibody (clone 6G5); Fab Fragment | ELISA | Human Fab |
HPAB-J0044-YC-F(E) | Rat Anti-CD4 Recombinant Antibody; Fab Fragment (HPAB-J0044-YC-F(E)) | ELISA, FC, CDC | Rat Fab |
HPAB-J0045-YC-F(E) | Rat Anti-CD4 Recombinant Antibody; Fab Fragment (HPAB-J0045-YC-F(E)) | ELISA, FC, CDC | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
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