Afuco™ Anti-CSF1R ADCC Recombinant Antibody (Cabiralizumab), ADCC Enhanced (CAT#: AFC-TAB-011ML)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CSF1R. Cabiralizumab is a human monoclonal antibody that can be potentially used in the treatment of Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/201_C4_2_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/201_C4_2_selected.jpg
Figure 2 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/29746_B_7_6_selected.jpg
(Immunohistochemical staining of human hippocampus shows cytoplasmic positivity in neuronal cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12323/29746_B_7_6_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_B_9_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_5.jpg
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_9_5.jpg
Figure 6 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_6_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8970/24179_A_6_6.jpg
Figure 7 RNA cell line category: Group enriched (BEWO, SK-BR-3)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182578-CSF1R
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182578-CSF1R
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Specificity
- Human CSF1R
- Species Reactivity
- Human
- Clone
- Cabiralizumab
- Applications
- ELISA, IHC, FC, IP, IF, Inhib
- Conjugate
- Unconjugated
- Generic Name
- Cabiralizumab
- Related Disease
- Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS)
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Colony stimulating factor 1 receptor; CSF-1R; CSF-1-R; macrophage colony-stimulating factor 1 receptor; c-fms; FMS; CD115
- Gene ID
- 1436
- UniProt ID
- P07333
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Cabiralizumab"
Anti-Human CSF1R Recombinant Antibody (Cabiralizumab)Recombinant monoclonal antibody to CSF1R. Cabiralizumab is a human monoclonal antibody that can be potentially used in the treatment of Rheumatoid arthritis (RA), Pigmented villonodular synovitis (PVNS).
See other products for "CSF1R"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1863z | Mouse Anti-CSF1R Recombinant Antibody (clone 32G11) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG2b |
| HPAB-0574-CN | Mouse Anti-CSF1R Recombinant Antibody (HPAB-0574-CN) | ELISA, Block | Mouse IgG |
| HPAB-0575-CN | Human Anti-CSF1R Recombinant Antibody (HPAB-0575-CN) | ELISA, Block | Chimeric (mouse/human) IgG4, κ |
| HPAB-0576-CN | Human Anti-CSF1R Recombinant Antibody (HPAB-0576-CN) | ELISA, Block | Humanized IgG4, κ |
| HPAB-0577-CN | Mouse Anti-CSF1R Recombinant Antibody (HPAB-0577-CN) | ELISA, FC | Mouse IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-H23 | Anti-Human CSF1R Recombinant Antibody (Emactuzumab) | WB, ELISA, IP, FC, FuncS, Neut, IF | IgG1 - kappa |
| TAB-078MZ | Human Anti-CSF1R Recombinant Antibody (TAB-078MZ) | ELISA | Humanized IgG |
| TAB-076MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-076MZ-S(P)) | WB | Human scFv |
| TAB-078MZ-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-078MZ-S(P)) | ELISA | Humanized scFv |
| TAB-011ML | Anti-Human CSF1R Recombinant Antibody (Cabiralizumab) | ELISA, IHC, FC, IP, IF, Inhib | IgG4, κ |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-178CL | Afuco™ Anti-CSF1R Recombinant Antibody (AFC-178CL), ADCC Enhanced | ELISA, WB | Human IgG1 |
| AFC-TAB-H23 | Afuco™ Anti-CSF1R ADCC Recombinant Antibody (Emactuzumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-055 | Human Anti-CSF1R Recombinant Antibody (clone RG7155); scFv Fragment | FC, FuncS | Mouse scFv |
| HPAB-0153-FY-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0153-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-0177-FY-S(P) | Human Anti-CSF1R Recombinant Antibody; scFv Fragment (HPAB-0177-FY-S(P)) | Block | Human scFv |
| HPAB-2085LY-S(P) | Human Anti-CSF1R Recombinant Antibody (clone 2F11-d8); scFv Fragment | ELISA | Human scFv |
| HPAB-2086LY-S(P) | Human Anti-CSF1R Recombinant Antibody (clone 2F11-f12); scFv Fragment | ELISA | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-077MZ | Mouse Anti-CSF1R Recombinant Antibody (TAB-077MZ) | ELISA | Mouse IgG2a, κ |
| TAB-079MZ | Anti-Mouse CSF1R Recombinant Antibody (AFS98) | FC | |
| TAB-077MZ-S(P) | Mouse Anti-CSF1R Recombinant Antibody; scFv Fragment (TAB-077MZ-S(P)) | ELISA | Mouse scFv |
| TAB-077MZ-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (TAB-077MZ-F(E)) | ELISA | Mouse Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-508CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL141) | Neut, WB | Mouse IgG1 |
| NEUT-509CQ | Mouse Anti-CSF1R Recombinant Antibody (clone CBL809) | WB, Neut | Mouse IgG1 |
| NEUT-510CQ | Mouse Anti-CSF1R Recombinant Antibody (clone MM0467-5V36) | WB, Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0825 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone DS825AB) | ELISA | Rabbit IgG |
| MOR-4112 | Hi-Affi™ Rabbit Anti-CSF1R Recombinant Antibody (clone SI183DS) | ELISA | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0073-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0073-LS-F(E)) | Block | Mouse Fab |
| HPAB-0074-LS-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0074-LS-F(E)) | Block | Human Fab |
| HPAB-0075-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0075-LS-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-0076-LS-F(E) | Mouse Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0076-LS-F(E)) | ELISA, Inhib | Mouse Fab |
| HPAB-0077-LS-F(E) | Human Anti-CSF1R Recombinant Antibody; Fab Fragment (HPAB-0077-LS-F(E)) | ELISA, Inhib | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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