Mouse Anti-DENV E Recombinant Antibody (clone 2H12) (CAT#: HPAB-S0024-YC)
2H12 binds to the highly conserved AB loop of domain III of the envelope protein that is poorly accessible in the mature virion. 2H12 neutralization varied between dengue serotypes and strains; in particular, dengue serotype 2 was not neutralized. Because the 2H12-binding epitope was conserved, this variation in neutralization highlights differences between dengue serotypes and suggests that significant conformational changes in the virus must take place for Ab binding. Surprisingly, 2H12 facilitated little or no enhancement of infection.
Specific Inquiry
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Dengue virus
- Species Reactivity
- DENV
- Clone
- 2H12
- Applications
- ELISA, Neut, FuncS
- Related Disease
- Dengue virus infections
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- DENV E; Envelope proteins; E proteins
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 2H12"
See other products for "DENV E"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-111 | Human Anti-DENV E Recombinant Antibody (clone DV10) | ELISA, NTRL | Human IgG |
| FAMAB-1690CQ | Human Anti-DENV E Recombinant Antibody (clone DVC21) | Neut, WB, ELISA, FC | Human IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0024-YC-F(E) | Mouse Anti-DENV E Recombinant Antibody (clone 2H12); Fab Fragment | ELISA, Neut, FuncS | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0024-YC-S(P) | Mouse Anti-DENV E Recombinant Antibody (clone 2H12); scFv Fragment | ELISA, Neut, FuncS | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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