Human Anti-DSG3 Recombinant Antibody (clone PVB16) (CAT#: FAMAB-1115CQ)
This product is a recombinant human antibody that recognizes DSG3. The antibody was purified by affinity chromatography. It can be used in ELISA, IF.
Specific Inquiry
ELISA
Figure 1 Binding of the indicated antibodies to DSG3-coated plates in the presence or absence of EDTA as assessed by ELISA.
Data are representative of 2 separate experiments (mean ± SEM).
Di Zenzo, G., Di Lullo, G., Corti, D., Calabresi, V., Sinistro, A., Vanzetta, F., ... & Amagai, M. (2012). Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface. The Journal of clinical investigation, 122(10), 3781-3790.
IF
Figure 2 Cryosections of human skin were stained with biotinylated human mAbs isolated from PV patients.
The cutaneous basement membrane zone is marked by a dotted line. Scale bars: 100 μm.
Di Zenzo, G., Di Lullo, G., Corti, D., Calabresi, V., Sinistro, A., Vanzetta, F., ... & Amagai, M. (2012). Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface. The Journal of clinical investigation, 122(10), 3781-3790.
IHC
Figure 3 Intraepidermal suprabasal blistering and acantholysis induced by injection into newborn mice of the indicated antibodies coadministered with ETA.
Data are representative of results obtained from groups of 5 mice. Original magnification, ×200.
Di Zenzo, G., Di Lullo, G., Corti, D., Calabresi, V., Sinistro, A., Vanzetta, F., ... & Amagai, M. (2012). Pemphigus autoantibodies generated through somatic mutations target the desmoglein-3 cis-interface. The Journal of clinical investigation, 122(10), 3781-3790.
Specifications
- Host Species
- Human
- Type
- Human IgG1
- Specificity
- EC5 domain of human desmoglein-3
- Species Reactivity
- Human
- Clone
- PVB16
- Applications
- IF, ELISA, IHC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Immunohistochemistry, Immunofluorescence and Enzyme-Linked Immunosorbent Assay.
Target
- Alternative Names
- Desmoglein 3; 130 KDa Pemphigus Vulgaris Antigen; Cadherin Family Member 6; CDHF6; PVA; Desmoglein 3 (Pemphigus Vulgaris Antigen); Pemphigus Vulgaris Antigen; Desmoglein-3
- Gene ID
- 1830
- UniProt ID
- P32926
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone PVB16"
See other products for "DSG3"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-258MZ | Anti-Human DSG3 Recombinant Antibody (DF151) | IHC, FC | |
| TAB-259MZ | Anti-Human DSG3 Recombinant Antibody (DF364) | IHC, FC | |
| TAB-260MZ | Anti-Human DSG3 Recombinant Antibody (DF366) | IHC, FC | |
| TAB-258MZ-F(E) | Anti-Human DSG3 Recombinant Antibody Fab Fragment (DF151) | IHC, FC | |
| TAB-259MZ-F(E) | Anti-Human DSG3 Recombinant Antibody Fab Fragment (DF364) | IHC, FC |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1055 | Hi-Affi™ Rabbit Anti-DSG3 Recombinant Antibody (clone DS1055AB) | WB | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0204-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3);3c/9); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0205-CN-S(P) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); scFv Fragment | ELISA, IF, IB | Human scFv |
| FAMAB-0152JF-S(P) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); scFv Fragment | IF, WB, ELISA, FuncS | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0203-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)1b/3a); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0204-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3c/9); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0205-CN-F(E) | Human Anti-DSG3 Recombinant Antibody (clone (D3)3a/9); Fab Fragment | ELISA, IF, IB | Human Fab |
| FAMAB-0152JF-F(E) | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786); Fab Fragment | IF, WB, ELISA, FuncS | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0152JF | Human Anti-DSG3 Recombinant Antibody (clone PVMAB786) | WB, ELISA, IHC, FuncS | Human IgG4 |
| FAMAB-1111CQ | Human Anti-DSG3 Recombinant Antibody (clone PVA224) | IF, ELISA, IHC | Human IgG1 |
| FAMAB-1113CQ | Mouse Anti-DSG3 Recombinant Antibody (clone PVB28) | IF, ELISA, IHC | Mouse IgG1 |
| FAMAB-1114CQ | Human Anti-DSG3 Recombinant Antibody (clone PVA232) | ELISA | Human IgG1 |
| FAMAB-1116CQ | Human Anti-DSG3 Recombinant Antibody (clone PVB124) | IF, ELISA, IHC | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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