This product is a recombinant antibody that recognizes EPOR. The monoclonal antibody Ab12.56 reacts with the epitope of EPOR.
Figure 1 EPO-dependent cell proliferation activity of Ab12 variants correlates inversely with Kd.
Ab variants with faster off-rates (Abs 12.6, 12.70, and 12.56) stimulate the proliferation of EPO-responsive F36E human erythroleukemic cells more effectively than does Ab12.
Lacy, S. E., DeVries, P. J., Xie, N., Fung, E., Lesniewski, R. R., & Reilly, E. B. (2008). The potency of erythropoietin-mimic antibodies correlates inversely with affinity. The Journal of Immunology, 181(2), 1282-1287.
Figure 2 CFU-E colony forming activity of Ab12 variants correlates inversely with Kd.
Compared with Ab12, Abs with faster off-rates (12.6, 12.70, and 12.56) are more effective, whereas Ab12.17 with a slower offrate is less effective at supporting the formation of erythroid colonies from hematopoietic precursor cells. rHu- EPO was used as a positive control.
Lacy, S. E., DeVries, P. J., Xie, N., Fung, E., Lesniewski, R. R., & Reilly, E. B. (2008). The potency of erythropoietin-mimic antibodies correlates inversely with affinity. The Journal of Immunology, 181(2), 1282-1287.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
PABW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007) | WB, FuncS | Human IgG |
MOB-0682CT | Recombinant Mouse anti-Human EPOR Monoclonal antibody (EML077) | WB | |
HPAB-1692-FY | Recombinant Human Anti-EPOR Antibody (Ab12) | Activ, FC, ELISA | Human IgG1 |
HPAB-1693-FY | Human Anti-EPOR Recombinant Antibody (clone Ab12.6) | FC, ELISA | Human IgG1 |
PABS-0017 | Human Anti-EpoR Diabody (Clone 330) | ELISA, FuncS | Human diabody |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007); Fab Fragment | WB, FuncS | Human Fab |
HPAB-0490-CN-F(E) | Mouse Anti-EPOR Recombinant Antibody (clone 21.3.1); Fab Fragment | ELISA, WB, ICC, IHC, IP | Mouse Fab |
HPAB-1692-FY-S(P) | Recombinant Human Anti-EPOR Antibody Fab Fragment (Ab12) | FC, ELISA | Human Fab |
HPAB-1693-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab12.6); Fab Fragment | FC, ELISA | Human Fab |
HPAB-1694-FY-S(P) | Human Anti-EPOR Recombinant Antibody (clone Ab12.56); Fab Fragment | FC, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-040 | Human Anti-EPOR Recombinant Antibody (clone ABT-007); scFv Fragment | WB, FuncS | Human scFv |
HPAB-1692-FY-F(E) | Recombinant Human Anti-EPOR Antibody scFv Fragment (Ab12) | FC, ELISA | Human scFv |
HPAB-1693-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab12.6); scFv Fragment | FC, ELISA | Human scFv |
HPAB-1694-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab12.56); scFv Fragment | FC, ELISA | Human scFv |
HPAB-1850-FY-F(E) | Human Anti-EPOR Recombinant Antibody (clone Ab198); scFv Fragment | Activ | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-007WM | Anti-Human EPOR Recombinant Antibody (AB-ABT2-XG2-012) | ELISA | Human Antibody |
TAB-007WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
TAB-007WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (AB-ABT2-XG2-012) | ELISA | Human Antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-008WM | Anti-Human EPOR Recombinant Antibody (1E3) | ELISA, WB, FC | |
TAB-008WM-S(P) | Anti-Human EPOR Recombinant Antibody scFv Fragment (1E3) | ELISA, WB, FC | |
TAB-009WM-S(P) | Mouse Anti-EPOR Recombinant Antibody; scFv Fragment (TAB-009WM-S(P)) | WB, FC | Mouse scFv |
TAB-008WM-F(E) | Anti-Human EPOR Recombinant Antibody Fab Fragment (1E3) | ELISA, WB, FC | |
TAB-009WM-F(E) | Mouse Anti-EPOR Recombinant Antibody; Fab Fragment (TAB-009WM-F(E)) | WB, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-736CQ | Mouse Anti-EPOR Recombinant Antibody (clone CBL641) | Neut | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1173 | Hi-Affi™ Rabbit Anti-EPOR Recombinant Antibody (clone DS1173AB) | IP, WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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