The crystal structure of F005-126 in complex with hemagglutinin revealed that the antibody binds to the globular head, spans a cleft formed by two hemagglutinin monomers in a hemagglutinin trimer, and cross-links them. It recognizes two peptide portions (sites L and R) and a glycan linked to asparagine at residue 285 using three complementarity-determining regions and framework 3 in the heavy chain. Binding of the antibody to sites L (residues 171 to 173, 239, and 240) and R (residues 91, 92, 270 to 273, 284, and 285) is mediated mainly by van der Waals contacts with the main chains of the peptides in these sites and secondarily by hydrogen bonds with a few side chains of conserved sequences in HA1. Furthermore, the glycan recognized by F005-126 is conserved among H3N2 viruses. F005-126 has the ability to prevent low-pH-induced conformational changes in hemagglutinin. The newly identified conserved epitope, including the glycan, should be immunogenic in humans and may induce production of broadly neutralizing antibodies against H3 viruses.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-203 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (3.1) | WB, ELISA, FuncS | Fab |
PFBL-204 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (39.29) | Neut, FuncS | Fab |
PFBL-205 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1957) | WB, Neut, FuncS | Fab |
PFBL-206 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PFBL-207 | Recombinant Human Anti-IAV HA Antibody Fab Fragment (5J8) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABL-482 | Recombinant Human Anti-H1N1 HA Antibody (CH65) | FuncS, Neut, WB | IgG |
PABL-483 | Recombinant Human Anti-H1N1 HA Antibody (CH67) | IF, FC | IgG |
PABL-484 | Recombinant Human Anti-H1N1 HA Antibody (I2) | Neut | IgG |
PABL-485 | Recombinant Mouse Anti-H1N1 HA Antibody | WB, ELISA, FuncS | IgG |
PABL-487 | Recombinant Human Anti-H2N2 HA Antibody (2G1 ) | FuncS | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-051 | Recombinant Mouse Anti-H3N2 NA Antibody scFv Fragment (Mem5) | WB, ELISA | scFv |
PFBC-160 | Human Anti-HA Recombinant Antibody; Fab Fragment (PFBC-160) | Neut, ELISA, FC | Human Fab |
PFBC-233 | Recombinant Human Anti-H3N2 HA Antibody Fab Fragment (F045-092) | Neut | Fab |
HPAB-0373-YJ-S(P) | Mouse Anti-HA Recombinant Antibody; scFv Fragment (HPAB-0373-YJ-S(P)) | ELISA, Neut, IF, FuncS | Mouse scFv |
HPAB-S0058-YC-S(P) | Mouse Anti-HA Recombinant Antibody (clone HC19); scFv Fragment | Neut | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-265CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D4-4) | WB, FC, IP | Human antibody |
MRO-266CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D4-5) | WB, FC, IP | Human antibody |
MRO-267CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D5-3) | WB, FC, IP | Human antibody |
MRO-268CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (D6-1) | WB, FC, IP | Human antibody |
MRO-269CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (IgA 59) | WB, Neut | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-308CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (8153) | WB, ELISA | |
MRO-309CT-F(E) | Anti-IAV HA Recombinant Antibody Fab Fragment (H36-7) | WB, ELISA | |
PABX-068-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (1F1) | WB, ELISA, FuncS | Fab |
PABX-069-F (E) | Recombinant Mouse Anti-Hemagglutinin(HA) Antibody Fab Fragment (S139/1 ) | ELISA, Neut, FuncS | Fab |
PABX-070-F (E) | Recombinant Mouse Anti-HA1 Antibody Fab Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-070-S (P) | Recombinant Mouse Anti-HA1 Antibody scFv Fragment (Fab17/9) | WB, ELISA, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4209 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI287DS) | ELISA, ICC/IF, IF, FC | IgG |
MOR-4210 | Hi-Affi™ Recombinant Rabbit Anti-HA Monoclonal Antibody (SI288DS) | ELISA, ICC/IF, IF, FC | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1169-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1169-FY) | Neut | Llama VHH |
HPAB-1170-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1170-FY) | Neut | Llama VHH |
HPAB-1171-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1171-FY) | Neut | Llama VHH |
HPAB-1172-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1172-FY) | Neut | Llama VHH |
HPAB-1173-FY | Llama Anti-HA Recombinant Single Domain Antibody (HPAB-1173-FY) | Neut | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-YF096 | DRB1*01:01/Influenza A HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF098 | DRB1*04:01/Influenza A HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF101 | DRB1*04:02/Influenza A HA (PKYVKQNTLKLAT) MHC Monomer | MHC Multimer | |
MHC-YF1042 | APC-DRB1*04:02/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM | |
MHC-YF1043 | APC-DRB1*07:01/Human HA (PKYVKQNTLKLAT) MHC Tetramer | FCM |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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