This product is a recombinant human antibody that can bind to HIV-1 gp120 with high affinity.
Figure 1 Identification of the CAP228-16H/19F UCA and Lambda IGLV3-21 GermlineAlleles.
ELISA binding of the CAP228-16H/19F UCA to an autologous transmitted/founder CAP228 V1V2 scaffolded protein.
van Eeden, C., Wibmer, C. K., Scheepers, C., Richardson, S. I., Nonyane, M., Lambson, B.,... & Bhiman, J. N. (2018). V2-directed vaccine-like antibodies from HIV-1 infection identify an additional K169-binding light chain motif with broad ADCC activity. Cell reports, 25(11), 3123-3135.
Figure 2 CAP228 antibodies efficiently inhibit α4β7 integrin binding.
Inhibition of ConC gp120 binding to α4β7 integrin transfected 293 T cells by V2p mAbs CAP228-16H (green), CAP228-3D (orange) or CH58 (blue). Percentage blocking (y-axis) was calculated from the difference in mean fluorescence intensity (MFI) when cell-gp120 complexes were made in the presence or absence of antibody. The α4β7 specific antibodies HP21 (purple) and ACT1 (red) were used as positive controls, while an irrelevant RSV antibody (palivizumab) and an HIV-1 CD4 binding site-specific antibody (VRC01) were used as the negative controls.
Wibmer, C. K., Richardson, S. I., Yolitz, J., Cicala, C., Arthos, J., Moore, P. L., & Morris, L. (2018). Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions. Nature communications, 9(1), 4489.
Figure 3 The α-helical form of V1V2 potentially engages the α4β7 integrin with high efficacy.
Endpoint ELISA binding titres of V2p mAbs CAP228-16H (green), CAP228-3D (orange) or CH59 (light blue), quaternary structure dependent V2q mAb PGT145 (purple) or V2i mAb 830 A (yellow) to concentrated pseudovirus expressing the C1080 envelope. HIV-1 CD4 binding site-specific antibody VRC01, and an irrelevant Flu-specific antibody were used as positive or negative controls, respectively.
Wibmer, C. K., Richardson, S. I., Yolitz, J., Cicala, C., Arthos, J., Moore, P. L., & Morris, L. (2018). Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions. Nature communications, 9(1), 4489.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-135 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PGT135) | ELISA, Neut | Human IgG |
PABL-142 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 412d) | Neut, WB, ELISA, FuncS | Human IgG |
PABL-155 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC03) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-156 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC-CH31) | WB, ELISA, Neut, FuncS | Human IgG |
PABL-160 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 59.1) | WB, ELISA, FuncS | Mouse IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-028LC-VHH) | ELISA | Single domain antibody |
MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-029LC-VHH) | ELISA | Single domain antibody |
MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-030LC-VHH) | ELISA | Single domain antibody |
MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-031LC-VHH) | ELISA | Single domain antibody |
MRO-032LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (MRO-032LC-VHH) | ELISA | Single domain antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-041LC | Anti-HIV-1 gp120 Recombinant Antibody (D59/A2) | ELISA | Mouse antibody |
MRO-042LC | Anti-HIV-1 gp120 Recombinant Antibody (F58/H3) | WB, ELISA | Mouse antibody |
MRO-043LC | Anti-HIV-1 gp120 Recombinant Antibody (P1/D12) | ELISA | Mouse antibody |
MRO-044LC | Anti-HIV-1 gp120 Recombinant Antibody (P4/D10) | ELISA | Mouse antibody |
MRO-045LC | Anti-HIV-1 gp120 Recombinant Antibody (A47/B1) | ELISA | Mouse antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-155LC | Anti-HIV-1 gp120 Recombinant Antibody (GP44) | ELISA | Human antibody |
MRO-156LC | Anti-HIV-1 gp120 Recombinant Antibody (GP68) | ELISA, Inhib | Human antibody |
MRO-157LC | Anti-HIV-1 gp120 Recombinant Antibody (MN215) | ELISA | Human antibody |
MRO-161LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-161LC) | ELISA | Human IgG1, κ |
MRO-162LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-162LC) | ELISA, FC, Neut, SPR | Human IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-3291CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 0.5γ (1C10)); Fab Fragment | Neut | Human Fab |
MRO-3292CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 28A11/B1); Fab Fragment | Neut | Human Fab |
MRO-3293CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 35F3/E2); Fab Fragment | Neut | Human Fab |
MRO-3377CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 14e (1.4e)); Fab Fragment | ELISA | Human Fab |
MRO-3378CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone NIH45-46G54F (45-46F)); Fab Fragment | Neut | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1990-FY-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 16c); scFv Fragment | WB | Human scFv |
HPAB-1991-FY-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 23e); scFv Fragment | WB | Human scFv |
FAMAB-0056WJ-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone L17); scFv Fragment | ELISA, Neut | Human scFv |
PSBS-0130 | Human Anti-HIV-1 gp120 Recombinant Antibody (Clone VRC01cHuGL2); scFv Fragment | ELISA, FuncS | Human scFv |
PABJ-0086-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone DH677.3); scFv Fragment | ELISA, ADCC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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