Recombinant Llama Anti-HIV-1 gp120 Single Domain Antibody (JM2) (CAT#: MRO-4372CQ)
Recombinant Llama Antibody to gp120. JM2 exhibited binding to CD4BS; neutralized only 1 of the 11 tier 1B, 2 and 3 viruses tested.
Specific Inquiry
ELISA
Figure 1 sdAb binding pattern on different conformations and strains of HIV-1 Env followed by ELISA.
JM1 and JM2 clones bind preferentially to the free form of Env.
Matz, J., Kessler, P., Bouchet, J., Combes, O., Ramos, O. H. P., Barin, F., ... & Chames, P. (2013). Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120. Journal of virology, 87(2), 1137-1149.
Neut
Figure 2 sdAb neutralization ability toward different pseudovirions strains.
Each sdAb was tested in a single-round neutralization using TZM-bl cells as target cells.
Matz, J., Kessler, P., Bouchet, J., Combes, O., Ramos, O. H. P., Barin, F., ... & Chames, P. (2013). Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120. Journal of virology, 87(2), 1137-1149.
Inhib
Figure 3 Binding of Env on sdAbs is expressed as the percentage of binding compared to the control (absence of competitor).
Data from one representative out of three independent 846 experiments are shown.
Matz, J., Kessler, P., Bouchet, J., Combes, O., Ramos, O. H. P., Barin, F., ... & Chames, P. (2013). Straightforward selection of broadly neutralizing single-domain antibodies targeting the conserved CD4 and coreceptor binding sites of HIV-1 gp120. Journal of virology, 87(2), 1137-1149.
Specifications
- Host Species
- Camelid
- Type
- Camelid VHH
- Specificity
- Recognizes HIV-1 gp120
- Species Reactivity
- HIV-1
- Clone
- JM2
- Applications
- ELISA, Neut, Inhib
Product Property
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 gp120 Single Domain antibody has been reported in applications of Enzyme-linked Immunosorbent Assay, Neutralization, Inhibition.
Target
- Alternative Names
- Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-082 | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| MRO-028LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91C2) | ELISA | Single domain antibody |
| MRO-029LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91F10) | ELISA | Single domain antibody |
| MRO-030LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91E1) | ELISA | Single domain antibody |
| MRO-031LC-VHH | Anti-HIV-1 gp120 Recombinant Antibody (L91B5) | ELISA | Single domain antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-380 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone VRC06); Fab Fragment | Neut, FuncS | Human Fab |
| FAMAB-0177CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone BAT123); Fab Fragment | Neut | Chimeric (mouse/human) Fab |
| FAMAB-0178CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone C beta 1); Fab Fragment | WB, Neut | Chimeric (mouse/human) Fab |
| MRO-3015CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 212A (2.12A)); Fab Fragment | ELISA | Human Fab |
| MRO-3016CQ-F(E) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 2-301); Fab Fragment | Neut | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-060 | Mouse Anti-HIV-1 gp120 Recombinant Antibody (clone 50.1) | Neut | Mouse IgG2a, κ |
| PABL-520 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 44-VRC13.01) | Neut | Human IgG |
| PABL-521 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 45-46M2) | ELISA, Neut | Human IgG |
| PABL-522 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 45-VRC01.H5.F-185917) | WB, FuncS | Human IgG |
| PABL-523 | Human Anti-HIV-1 gp120 Recombinant Antibody (clone 8ANC131) | WB, FuncS | Human IgG |
scFv Fragment Antibody
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-125LC | Anti-HIV-1 gp120 Recombinant Antibody (N6) | Neut, ELISA | Human antibody |
| MRO-130LC | Human Anti-HIV-1 gp120 Recombinant Antibody (MRO-130LC) | ELISA, Neut, SPR | Human IgG |
| MRO-136LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900973) | ELISA | Human antibody |
| MRO-137LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900972) | ELISA | Human antibody |
| MRO-138LC | Anti-HIV-1 gp120 Recombinant Antibody (Ab900990) | ELISA | Human antibody |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-135LC | Anti-HIV-1 gp120 Recombinant Antibody (CAG1-51-4) | ELISA, WB, Neut | Chimeric antibody (mouse/human) |
| MRO-135LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
| MRO-135LC-F(E) | Anti-HIV-1 gp120 Recombinant Antibody Fab Fragment (CAG1-51-4) | ELISA, WB | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-041LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (D59/A2) | ELISA | Mouse antibody |
| MRO-042LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (F58/H3) | ELISA | Mouse antibody |
| MRO-043LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P1/D12) | ELISA | Mouse antibody |
| MRO-044LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (P4/D10) | ELISA | Mouse antibody |
| MRO-045LC-S(P) | Anti-HIV-1 gp120 Recombinant Antibody scFv Fragment (A47/B1) | ELISA | Mouse antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4220 | Rabbit Anti-HIV-1 gp120 Recombinant Antibody (clone SI299DS) | WB, ELISA | Rabbit IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-101-S(P) | Human Anti-HIV-1 gp120 Recombinant Antibody (clone PG9); scFv Fragment | WB, ELISA, FuncS | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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