Recombinant monoclonal antibody specially binds to HIV-1 reverse transcriptase. 7C4 is a mouse monoclonal antibody that can specifically and almost completely inhibit the RNAdependent DNA polymerase activity of HIV-1 reverse transcriptase.
Figure 1 Western blot analysis of 7C4.
Western blot analysis of monoclonal antibodies to purified recombinant RT prepared from E. coli.
Chiba, J., Nakano, M., Suzuki, Y., Aoyama, K., Ohba, H., Kobayashi, T., Yasuda, A., Kojima, A., & Kurata, T. (1997). Generation of neutralizing antibody to the reverse transcriptase of human immunodeficiency virus type 1 by immunizing of mice with an infectious vaccinia virus recombinant. Journal of immunological methods, 207(1), 53–60.
Figure 2 Inhibitory activity of monoclonal antibodies to RNA-dependent DNA polymerase activity of HIV-1 RT.
Almost complete inhibition of RT activity was observed by preincubation with 7C4.
Chiba, J., Nakano, M., Suzuki, Y., Aoyama, K., Ohba, H., Kobayashi, T., Yasuda, A., Kojima, A., & Kurata, T. (1997). Generation of neutralizing antibody to the reverse transcriptase of human immunodeficiency virus type 2 by immunizing of mice with an infe
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-491 | Recombinant Anti-HIV-1 RT Antibody | ELISA, WB, FuncS | IgG |
MHH-491 | Recombinant Human Anti-HIV-1 RT Antibody | WB, IF, FuncS | IgG |
PABW-070 | Mouse Anti-HIV-1 RT Recombinant Antibody (clone 28) | WB, FuncS | Mouse IgG |
MRO-1011CQ | Mouse Anti-HIV-1 RT Recombinant Antibody (clone 39/4.12.2) | ELISA, WB | Mouse IgG1 |
MRO-1012CQ | Mouse Anti-HIV-1 RT Recombinant Antibody (clone 5B2B2) | ELISA, IF | Mouse IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-491-F(E) | Recombinant Anti-HIV-1 RT Antibody Fab Fragment | IF, ELISA, FuncS | Fab |
MHH-491-F(E) | Recombinant Human Anti-HIV-1 RT Antibody Fab Fragment | ELISA, WB, Neut, FuncS | Fab |
PFBW-070 | Mouse Anti-HIV-1 RT Recombinant Antibody (clone 28); Fab Fragment | WB, FuncS | Mouse Fab |
FAMAB-0185CQ-F(E) | Mouse Anti-HIV-1 RT Recombinant Antibody (clone MAb 3); Fab Fragment | ELISA, WB, Neut, IF | Mouse Fab |
FAMAB-0297JF-F(E) | Mouse Anti-HIV-1 RT Recombinant Antibody (clone 7C4); Fab Fragment | ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-491-S(P) | Recombinant Anti-HIV-1 RT Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
MHH-491-S(P) | Recombinant Human Anti-HIV-1 RT Antibody scFv Fragment | Neut, IF, FuncS | scFv |
PSBW-070 | Mouse Anti-HIV-1 RT Recombinant Antibody (clone 28); scFv Fragment | WB, FuncS | Mouse scFv |
FAMAB-0185CQ-S(P) | Mouse Anti-HIV-1 RT Recombinant Antibody (clone MAb 3); scFv Fragment | ELISA, WB, Neut, IF | Mouse scFv |
FAMAB-0297JF-S(P) | Mouse Anti-HIV-1 RT Recombinant Antibody (clone 7C4); scFv Fragment | ELISA, FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-CN0829 | PE-B*35:01/HIV-1 RT (VPLDEDFRKY) MHC Tetramer | FCM, IHC | |
MHC-CN0830 | APC-B*35:01/HIV-1 RT (VPLDEDFRKY) MHC Tetramer | FCM, IHC | |
MHC-CN0831 | FITC-B*35:01/HIV-1 RT (VPLDEDFRKY) MHC Tetramer | FCM, IHC | |
MHC-CN0832 | B*35:01/HIV-1 RT (VPLDEDFRKY) MHC Tetramer | FCM, IHC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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