Recombinant monoclonal antibody specially binds to the CD40 binding site of HIV gp120 and gp140. This human anti-gp120 antibody (m14) is a novel CD4bs cross-reactive HIV-1 neutralizing antibody that exhibits a novel inhibitory profile, and may have implications for our understanding of the mechanisms of immune evasion and for the development of inhibitors and vaccines.
Figure 1 Representative images of gp120 exposed primary mixed human CNS aggregate cultures at 4 weeks in vitro after Asc-p supplementation.
Error bars: +/- 1 standard error.
Walsh, K. A., Megyesi, J. F., Wilson, J. X., Crukley, J., Laubach, V. E., & Hammond, R. R. (2004). Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity. Journal of neuroinflammation, 1(1), 1-14.
Figure 2 Immunofluorescence imaging by confocal microscopy was performed for detection of iNOS antigens.
Each panel of images shows individual fluorophores and merged fluorophores with colocalization represented in yellow.
Walsh, K. A., Megyesi, J. F., Wilson, J. X., Crukley, J., Laubach, V. E., & Hammond, R. R. (2004). Antioxidant protection from HIV-1 gp120-induced neuroglial toxicity. Journal of neuroinflammation, 1(1), 1-14.
Figure 3 Western blot analysis of the gp120 on the patient samples.
Molecular weight standards are shown at the right.
Bettaieb, A., Oksenhendler, E., Duedari, N., & Bierling, P. (1996). Cross‐reactive antibodies between HIV‐gp120 and platelet gpIIIa (CD61) in HIV‐related immune thrombocytopenic purpura. Clinical & Experimental Immunology, 103(1), 19-23.
Figure 4 Recognition of recombinant HIV-1 gp120-coated and HIV-1 infected target cells by specific anti-gp120 antibodies.
Data shown are the results of at least 3 independent experiments.
Parekh, B. S., Shaffer, N., Pau, C. P., Abrams, E., Thomas, P., Pollack, H., ... & Rogers, M. (1991). Lack of correlation between maternal antibodies to V3 loop peptides of gp120 and perinatal HIV-1 transmission. The NYC Perinatal HIV Transmission Collaborative Study. AIDS (London, England), 5(10), 1179-1184.
Figure 5 Binding specificities of mAb is determined by ELISA.
All results are representative of at least four independent experiments.
Devico, L., Rahman, R., Welch, J., Crowley, R., Lusso, P., Sarngadharan, M. G., & Pal, R. (1995). Monoclonal antibodies raised against covalently crosslinked complexes of human immunodeficiency virus type 1 gp120 and CD4 receptor identify a novel complex-dependent epitope on gp120. Virology, 211(2), 583-588.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-412 | Recombinant Anti-HIV gp120 Antibody | ELISA, WB, Dot, FuncS | IgG |
HPAB-1452-FY | Human Anti-HIV gp120 Recombinant Antibody (HPAB-1452-FY) | Neut, ELISA, FC, Block | Human IgG |
HPAB-1454-FY | Human Anti-HIV gp120 Recombinant Antibody (HPAB-1454-FY) | Neut, ELISA, FC, Block | Human IgG |
HPAB-1859-FY | Human Anti-HIV gp120 Recombinant Antibody (clone pMT4-3) | Neut | Human IgG |
FAMAB-0080WJ | Human Anti-HIV gp120 Recombinant Antibody (clone NO.13) | ELISA, WB | Human IgG1, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-412-F(E) | Recombinant Anti-HIV gp120 Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
MHH-412-F(E) | Recombinant Human Anti-HIV gp120 Antibody Fab Fragment | Neut, IF, FuncS | Fab |
HPAB-1859-FY-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone pMT4-3); Fab Fragment | Neut | Human Fab |
FAMAB-0080WJ-F(E) | Human Anti-HIV gp120 Recombinant Antibody (clone NO.13); Fab Fragment | ELISA, WB | Human Fab |
FAMAB-0081WJ-F(E) | Human Anti-HIV gp120 Recombinant Antibody (clone S1-1); Fab Fragment | ELISA, WB | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
IAB-B053(A) | Recombinant Anti-HIV gp120 Intrabody [(D-Arg)9] | ELISA, ICC, FuncS | scFv-(D-Arg)9 |
IAB-B053(G) | Recombinant Anti-HIV gp120 Intrabody [+36 GFP] | PCA, Neut, FuncS | scFv-(+36GFP) |
CAT | Product Name | Application | Type |
---|---|---|---|
MHH-412-S(P) | Recombinant Human Anti-HIV gp120 Antibody scFv Fragment | ELISA, IP, FuncS | scFv |
FAMAB-0232JF-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone 257-D); scFv Fragment | ELISA, FuncS | Human scFv |
FAMAB-0242JF-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone m14); scFv Fragment | ELISA, FuncS | Human scFv |
FAMAB-0290JF-S(P) | Human Anti-HIV gp120 Recombinant Antibody (clone JL427); scFv Fragment | ELISA, FuncS | Human scFv |
PABJ-0031-S(P) | Bovine Anti-HIV gp120 Recombinant Antibody; scFv Fragment (PABJ-0031-S(P)) | ELISA, Neut | Bovine scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-182LC | Anti-HIV gp120 Recombinant Antibody (58.2) | ELISA | Human antibody |
MRO-183LC | Anti-HIV gp120 Recombinant Antibody (59.1) | ELISA | Human antibody |
MRO-182LC-S(P) | Anti-HIV gp120 Recombinant Antibody scFv Fragment (58.2) | ELISA | Human antibody |
MRO-182LC-F(E) | Anti-HIV gp120 Recombinant Antibody Fab Fragment (58.2) | ELISA | Human antibody |
MRO-183LC-F(E) | Anti-HIV gp120 Recombinant Antibody Fab Fragment (59.1) | ELISA | Human antibody |
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